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The –A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis
Affiliations- Clinical Department of Neurology, Voivodeship Hospital in Olsztyn
- Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
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Abstract
Sporadic amyotrophic lateral sclerosis (sALS) is a devastating neurodegenerative disease, which results from complex genetic and environmental interactions. Recent studies have reported an association between several polymorphisms of the PON1 and PON2 genes and risk of sALS. The aim of the present study was to identify an association between the – A162G polymorphism of the promoter region of the human PON1 gene and the risk of sALS in a Polish population.
Material and methodsWe included 259 patients with a diagnosis of definite or probable sALS (76 bulbar onset, 183 limb onset) and 694 healthy controls matched for age and sex. The diagnosis of ALS was established according to El Escorial criteria. The polymorphism was studied by Single Nucleotide Polymorphism Real-Time Polymerase Chain Reaction analysis.
ResultsNo overall difference in the PONI – A162G genotype and allele distribution was seen between cases and controls (all p > 0.05). There was, however, a difference in the A allele frequency when the bulbar onset group was compared to the controls (p = 0.03), but this significance disappeared after the Bonferroni correction.
ConclusionsThe results did not show that the – A162G polymorphism of the PON1 gene is a risk factor of sALS in a Polish population; it may affect, however, bulbar onset of the disease.
Abstract
Sporadic amyotrophic lateral sclerosis (sALS) is a devastating neurodegenerative disease, which results from complex genetic and environmental interactions. Recent studies have reported an association between several polymorphisms of the PON1 and PON2 genes and risk of sALS. The aim of the present study was to identify an association between the – A162G polymorphism of the promoter region of the human PON1 gene and the risk of sALS in a Polish population.
Material and methodsWe included 259 patients with a diagnosis of definite or probable sALS (76 bulbar onset, 183 limb onset) and 694 healthy controls matched for age and sex. The diagnosis of ALS was established according to El Escorial criteria. The polymorphism was studied by Single Nucleotide Polymorphism Real-Time Polymerase Chain Reaction analysis.
ResultsNo overall difference in the PONI – A162G genotype and allele distribution was seen between cases and controls (all p > 0.05). There was, however, a difference in the A allele frequency when the bulbar onset group was compared to the controls (p = 0.03), but this significance disappeared after the Bonferroni correction.
ConclusionsThe results did not show that the – A162G polymorphism of the PON1 gene is a risk factor of sALS in a Polish population; it may affect, however, bulbar onset of the disease.
Keywords
amyotrophic lateral sclerosis, PON1, polymorphism
About this articleTitle
The –A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
246-250
Page views
251
Article views/downloads
313
DOI
10.1016/S0028-3843(14)60038-4
Bibliographic record
Neurol Neurochir Pol 2010;44(3):246-250.
Keywords
amyotrophic lateral sclerosis
PON1
polymorphism
Authors
Dorota Zawiślak
Monika Ostrowska
Aleksandra Golenia
Monika Marona
Barbara Tomik
Paweł Wołkow
Elżbieta Gryz-Kurek
Andrzej Szczudlik
Agnieszka Słowik
