open access

Vol 44, No 2 (2010)
OPIS PRZYPADKU
Submitted: 2009-05-27
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Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion – case report and a review of the literature

Anna Mosiewicz, Radosław Rola, Bożena Jarosz, Agnieszka Trojanowska, Tomasz Trojanowski
DOI: 10.1016/S0028-3843(14)60011-6
·
Neurol Neurochir Pol 2010;44(2):196-203.

open access

Vol 44, No 2 (2010)
OPIS PRZYPADKU
Submitted: 2009-05-27

Abstract

Langerhans cell histiocytosis is a rare neoplasm that belongs to the histiocytic and dendritic cell neoplasm group according to the 2008 WHO classification. It has been defined as neoplastic proliferation of Langerhans cells that express CD1a and S-100 proteins and have Birbeck granules on the ultrastructural examination. Clinical presentation and behaviour are heterogeneous and can range from a solitary lytic bone lesion with a favourable course to a fatal disseminated leukaemia-like form, with a wide spectrum of intermediate clinical presentations between these two extremes. Here, we present a case report of a solitary calvarial lesion in an adolescent boy along with a review of the literature. Presenting features, initial diagnostic evaluation and treatment protocol of a unifocal monosystemic calvarial location of LCH are presented.

Abstract

Langerhans cell histiocytosis is a rare neoplasm that belongs to the histiocytic and dendritic cell neoplasm group according to the 2008 WHO classification. It has been defined as neoplastic proliferation of Langerhans cells that express CD1a and S-100 proteins and have Birbeck granules on the ultrastructural examination. Clinical presentation and behaviour are heterogeneous and can range from a solitary lytic bone lesion with a favourable course to a fatal disseminated leukaemia-like form, with a wide spectrum of intermediate clinical presentations between these two extremes. Here, we present a case report of a solitary calvarial lesion in an adolescent boy along with a review of the literature. Presenting features, initial diagnostic evaluation and treatment protocol of a unifocal monosystemic calvarial location of LCH are presented.

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Keywords

Langerhans cell histiocytosis, case report, treatment protocol

About this article
Title

Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion – case report and a review of the literature

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 44, No 2 (2010)

Pages

196-203

DOI

10.1016/S0028-3843(14)60011-6

Bibliographic record

Neurol Neurochir Pol 2010;44(2):196-203.

Keywords

Langerhans cell histiocytosis
case report
treatment protocol

Authors

Anna Mosiewicz
Radosław Rola
Bożena Jarosz
Agnieszka Trojanowska
Tomasz Trojanowski

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