Vol 44, No 1 (2010)

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The role of the PTEN gene in malignant gliomas

George A. Alexiou1, Spyridon Voulgaris1
DOI: 10.1016/S0028-3843(14)60408-4
Neurol Neurochir Pol 2010;44(1):80-86.


This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.

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Neurologia i Neurochirurgia Polska