open access
The role of the PTEN gene in malignant gliomas
- department of neurosurgery
open access
Abstract
This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.
Abstract
This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.
Keywords
PTEN, AKT, glioma
Title
The role of the PTEN gene in malignant gliomas
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
80-86
Page views
349
Article views/downloads
1281
DOI
10.1016/S0028-3843(14)60408-4
Bibliographic record
Neurol Neurochir Pol 2010;44(1):80-86.
Keywords
PTEN
AKT
glioma
Authors
George A. Alexiou
Spyridon Voulgaris