open access

Vol 44, No 1 (2010)
ARTYKUŁ POGLĄDOWY
Submitted: 2009-09-23
Get Citation

The role of the PTEN gene in malignant gliomas

George A. Alexiou, Spyridon Voulgaris
DOI: 10.1016/S0028-3843(14)60408-4
·
Neurol Neurochir Pol 2010;44(1):80-86.

open access

Vol 44, No 1 (2010)
ARTYKUŁ POGLĄDOWY
Submitted: 2009-09-23

Abstract

This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.

Abstract

This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.

Get Citation

Keywords

PTEN, AKT, glioma

About this article
Title

The role of the PTEN gene in malignant gliomas

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 44, No 1 (2010)

Pages

80-86

DOI

10.1016/S0028-3843(14)60408-4

Bibliographic record

Neurol Neurochir Pol 2010;44(1):80-86.

Keywords

PTEN
AKT
glioma

Authors

George A. Alexiou
Spyridon Voulgaris

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl