open access

Vol 4, No 3 (2019)
REVIEW ARTICLES
Published online: 2019-05-09
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The interplay between bone, muscle and adipose tissue — is there a role for potential new metabolic biomarker?

Wojciech Biliński, Przemysław T. Paradowski, Grażyna Sypniewska
DOI: 10.5603/MRJ.a2019.0023
·
Medical Research Journal 2019;4(3):171-173.

open access

Vol 4, No 3 (2019)
REVIEW ARTICLES
Published online: 2019-05-09

Abstract

Recent studies in mice and humans have shown the tight connection between bone and muscle tissues.
Physical activity affects the function of osteocytes, mature bone cells, stimulating the synthesis of several
hormone-like myokines in skeletal muscles. Anabolic action of physical exercise on bone is mediated by
a myokine called irisin. This protein was initially assigned to regulate glucose homeostasis in humans
but recently the influence of irisin on bone and adipose tissue metabolism was also demonstrated. In
the human blood, irisin occurs in different forms, free or complexed, glycosylated and non-glycosylated
which makes a reliable and reproducible measurement of this protein a crucial issue for the clinical interpretation of experimental findings. In humans, irisin was shown to inversely correlate with the prevalence
of bone fractures. Data obtained so far suggest that irisin could be a potential target for the treatment of
osteoporosis and play an important role in the bone healing process.

Abstract

Recent studies in mice and humans have shown the tight connection between bone and muscle tissues.
Physical activity affects the function of osteocytes, mature bone cells, stimulating the synthesis of several
hormone-like myokines in skeletal muscles. Anabolic action of physical exercise on bone is mediated by
a myokine called irisin. This protein was initially assigned to regulate glucose homeostasis in humans
but recently the influence of irisin on bone and adipose tissue metabolism was also demonstrated. In
the human blood, irisin occurs in different forms, free or complexed, glycosylated and non-glycosylated
which makes a reliable and reproducible measurement of this protein a crucial issue for the clinical interpretation of experimental findings. In humans, irisin was shown to inversely correlate with the prevalence
of bone fractures. Data obtained so far suggest that irisin could be a potential target for the treatment of
osteoporosis and play an important role in the bone healing process.

Get Citation

Keywords

bone, muscle, adipose tissue, myokines, irisin, bone fractures

About this article
Title

The interplay between bone, muscle and adipose tissue — is there a role for potential new metabolic biomarker?

Journal

Medical Research Journal

Issue

Vol 4, No 3 (2019)

Pages

171-173

Published online

2019-05-09

DOI

10.5603/MRJ.a2019.0023

Bibliographic record

Medical Research Journal 2019;4(3):171-173.

Keywords

bone
muscle
adipose tissue
myokines
irisin
bone fractures

Authors

Wojciech Biliński
Przemysław T. Paradowski
Grażyna Sypniewska

References (28)
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