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The interplay between bone, muscle and adipose tissue — is there a role for potential new metabolic biomarker?
open access
Abstract
Recent studies in mice and humans have shown the tight connection between bone and muscle tissues.
Physical activity affects the function of osteocytes, mature bone cells, stimulating the synthesis of several
hormone-like myokines in skeletal muscles. Anabolic action of physical exercise on bone is mediated by
a myokine called irisin. This protein was initially assigned to regulate glucose homeostasis in humans
but recently the influence of irisin on bone and adipose tissue metabolism was also demonstrated. In
the human blood, irisin occurs in different forms, free or complexed, glycosylated and non-glycosylated
which makes a reliable and reproducible measurement of this protein a crucial issue for the clinical interpretation of experimental findings. In humans, irisin was shown to inversely correlate with the prevalence
of bone fractures. Data obtained so far suggest that irisin could be a potential target for the treatment of
osteoporosis and play an important role in the bone healing process.
Abstract
Recent studies in mice and humans have shown the tight connection between bone and muscle tissues.
Physical activity affects the function of osteocytes, mature bone cells, stimulating the synthesis of several
hormone-like myokines in skeletal muscles. Anabolic action of physical exercise on bone is mediated by
a myokine called irisin. This protein was initially assigned to regulate glucose homeostasis in humans
but recently the influence of irisin on bone and adipose tissue metabolism was also demonstrated. In
the human blood, irisin occurs in different forms, free or complexed, glycosylated and non-glycosylated
which makes a reliable and reproducible measurement of this protein a crucial issue for the clinical interpretation of experimental findings. In humans, irisin was shown to inversely correlate with the prevalence
of bone fractures. Data obtained so far suggest that irisin could be a potential target for the treatment of
osteoporosis and play an important role in the bone healing process.
Keywords
bone, muscle, adipose tissue, myokines, irisin, bone fractures
About this articleTitle
The interplay between bone, muscle and adipose tissue — is there a role for potential new metabolic biomarker?
Journal
Issue
Article type
Review article
Pages
171-173
Published online
2019-05-09
Page views
789
Article views/downloads
921
DOI
Bibliographic record
Medical Research Journal 2019;4(3):171-173.
Keywords
bone
muscle
adipose tissue
myokines
irisin
bone fractures
Authors
Wojciech Biliński
Przemysław T. Paradowski
Grażyna Sypniewska
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