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Expression of KIM-1, VEGF and bFGF in the transplanted kidney as predictive factors of kidney allograft function
Affiliations- Department of General, Minimally Invasive, and Gastroenterological Surgery, Pomeranian Medical University in Szczecin, Poland
- Department of Internal Diseases, Pomeranian Medical University in Szczecin, Poland
- Department of Nephrology, Transplantology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland
- Clinic of Paediatrics, Nephrology, Dialysis and Treatment of Acute Poisonings, Pomeranian Medical University, Szczecin, Poland
- Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
- Department of Physiology, Pomeranian Medical University, Szczecin, Poland
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Abstract
Introduction: Transplantation is now a common treatment for kidney failure. However, it is associated with numerous complications, among which is rejection. Currently, factors that can predict the function of the transplanted kidney are being sought. This study aimed to investigate whether the expression of KIM-1 (kidney injury molecule-1), VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) assessed in the transplanted kidney before transplantation can be a predictive marker of the later function of the transplanted kidney and the occurrence of complications such as delayed graft function (DGF) and acute rejection (AR).
Material and methods: The study group included 44 kidney allograft recipients who underwent kidney transplantation.
Results: There were no statistically significant correlations between KIM-1, VEGF and bFGF gene expression in transplanted kidney biopsies and the occurrence of DGF and AR. The expression of the bFGF gene correlated significantly with the creatinine levels before and on the first day after transplantation. There were no statistically significant correlations between creatinine levels and expression of the KIM-1 and VEGF genes. There was also no statistically significant correlation between bFGF, KIM-1 and VEGF gene expression in the transplanted kidney and later eGFR and diuresis values. A statistically significant negative correlation was found between bFGF and serum potassium levels before transplantation and up to one month after transplantation. KIM-1 expression correlated significantly negatively with pre-transplant serum potassium levels. VEGF expression correlated significantly negatively with potassium levels 2 and 24 months after transplantation.
Conclusions: The present results suggest that the expression of KIM-1, VEGF and bFGF assessed in the transplanted kidney before transplantation is not a significant predictor of the later function of the transplanted kidney. The expression of the bFGF gene correlates with the creatinine levels before and on the first day after transplantation. The expression of KIM-1, VEGF and bFGF may correlate with potassium serum levels.
Abstract
Introduction: Transplantation is now a common treatment for kidney failure. However, it is associated with numerous complications, among which is rejection. Currently, factors that can predict the function of the transplanted kidney are being sought. This study aimed to investigate whether the expression of KIM-1 (kidney injury molecule-1), VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) assessed in the transplanted kidney before transplantation can be a predictive marker of the later function of the transplanted kidney and the occurrence of complications such as delayed graft function (DGF) and acute rejection (AR).
Material and methods: The study group included 44 kidney allograft recipients who underwent kidney transplantation.
Results: There were no statistically significant correlations between KIM-1, VEGF and bFGF gene expression in transplanted kidney biopsies and the occurrence of DGF and AR. The expression of the bFGF gene correlated significantly with the creatinine levels before and on the first day after transplantation. There were no statistically significant correlations between creatinine levels and expression of the KIM-1 and VEGF genes. There was also no statistically significant correlation between bFGF, KIM-1 and VEGF gene expression in the transplanted kidney and later eGFR and diuresis values. A statistically significant negative correlation was found between bFGF and serum potassium levels before transplantation and up to one month after transplantation. KIM-1 expression correlated significantly negatively with pre-transplant serum potassium levels. VEGF expression correlated significantly negatively with potassium levels 2 and 24 months after transplantation.
Conclusions: The present results suggest that the expression of KIM-1, VEGF and bFGF assessed in the transplanted kidney before transplantation is not a significant predictor of the later function of the transplanted kidney. The expression of the bFGF gene correlates with the creatinine levels before and on the first day after transplantation. The expression of KIM-1, VEGF and bFGF may correlate with potassium serum levels.
Keywords
KIM-1, VEGF, bFGF, kidney, allograft
About this articleTitle
Expression of KIM-1, VEGF and bFGF in the transplanted kidney as predictive factors of kidney allograft function
Journal
Issue
Article type
Original article
Pages
234-241
Published online
2023-08-22
Page views
147
Article views/downloads
252
DOI
Bibliographic record
Medical Research Journal 2023;8(3):234-241.
Keywords
KIM-1
VEGF
bFGF
kidney
allograft
Authors
Tadeusz Sulikowski
Agnieszka Orłowska-Szafrańska
Jan Pawlus
Jarosław Lichota
Kazimierz Ciechanowski
Małgorzata Marchelek-Myśliwiec
Andrzej Brodkiewicz
Krzysztof Safranow
Leszek Domański
Andrzej Pawlik
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