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Published online: 2024-08-08

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Antiangiogenic effects in the modulation of inflammatory pathways. A comprehensive analysis of potential therapeutic substances.

Klaudia Piekarska1, Dominika Spyt1, Klaudia Bonowicz12, Dominika Jerka1, Alina Grzanka1, Maciej Gagat12

Abstract

Based on current knowledge antiangiogenic compounds are utilized in the treatment of inflammatory-depended diseases such as cancer. It has been shown that these compounds can simultaneously block several signaling pathways regulating angiogenesis. The visualization of fluorescently labeled F-actin and VE-cadherin was allowed to demonstrate that the reorganization of the cell cytoskeleton disrupts cellular processes and consequently inhibits angiogenesis.

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References

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