Tom 16, Nr 2 (2023)
Artykuł przeglądowy
Opublikowany online: 2023-04-28
Wyświetlenia strony
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Wpływ stresu proliferacyjnego na nabytą i wrodzoną odpowiedź immunologiczną
Journal of Transfusion Medicine 2023;16(2):97-102.
Streszczenie
Starzenie się człowieka jest wciąż uznawane za jedno z najbardziej złożonych zjawisk w biologii. Dotyka wszystkich komórek i tkanek, prowadząc do stopniowej utraty ich funkcji, spadku ich aktywności podziałowej oraz wadliwej odpowiedzi komórkowej na bodźce. Jednym z głównych mechanizmów starzenia komórkowego jest stres proliferacyjny, który skutkuje skracaniem się telomerów, uszkodzeniem DNA oraz odkładaniem się w komórkach białek wtrętowych. Allogeniczne przeszczepienie krwiotwórczych komórek progenitorowych (allo-HCT) może służyć jako dobry model starzenia komórkowego. W niniejszej pracy podsumowano proces starzenia się układu immunologicznego i wpływ stresu proliferacyjnego na wrodzoną i nabytą odpowiedź immunologiczną, której wykładnikiem są zjawiska immunosenescencji oraz inflammagingu, w kontekście jatrogennego stresu proliferacyjnego, indukowanego przez allo-HCT.
Słowa kluczowe: immunosenescencjainflammagingallo-HCTstres proliferacyjny
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