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Vol 16, No 2 (2023)
Review paper
Published online: 2023-04-28
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Wpływ stresu proliferacyjnego na nabytą i wrodzoną odpowiedź immunologiczną

Michał Cezary Czarnogórski1, Jacek M. Witkowski2, Jan M. Zaucha1
Journal of Transfusion Medicine 2023;16(2):97-102.
Affiliations
  1. Katedra i Klinika Hematologii i Transplantologii, Gdański Uniwersytet Medyczny, Gdańsk
  2. Katedra i Zakład Fizjopatologii, Gdański Uniwersytet Medyczny, Gdańsk

open access

Vol 16, No 2 (2023)
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Published online: 2023-04-28

Abstract

Starzenie się człowieka jest wciąż uznawane za jedno z najbardziej złożonych zjawisk w biologii. Dotyka wszystkich komórek i tkanek, prowadząc do stopniowej utraty ich funkcji, spadku ich aktywności podziałowej oraz wadliwej odpowiedzi komórkowej na bodźce. Jednym z głównych mechanizmów starzenia komórkowego jest stres proliferacyjny, który skutkuje skracaniem się telomerów, uszkodzeniem DNA oraz odkładaniem się w komórkach białek wtrętowych. Allogeniczne przeszczepienie krwiotwórczych komórek progenitorowych (allo-HCT) może służyć jako dobry model starzenia komórkowego. W niniejszej pracy podsumowano proces starzenia się układu immunologicznego i wpływ stresu proliferacyjnego na wrodzoną i nabytą odpowiedź immunologiczną, której wykładnikiem są zjawiska immunosenescencji oraz inflammagingu, w kontekście jatrogennego stresu proliferacyjnego, indukowanego przez allo-HCT.

Abstract

Starzenie się człowieka jest wciąż uznawane za jedno z najbardziej złożonych zjawisk w biologii. Dotyka wszystkich komórek i tkanek, prowadząc do stopniowej utraty ich funkcji, spadku ich aktywności podziałowej oraz wadliwej odpowiedzi komórkowej na bodźce. Jednym z głównych mechanizmów starzenia komórkowego jest stres proliferacyjny, który skutkuje skracaniem się telomerów, uszkodzeniem DNA oraz odkładaniem się w komórkach białek wtrętowych. Allogeniczne przeszczepienie krwiotwórczych komórek progenitorowych (allo-HCT) może służyć jako dobry model starzenia komórkowego. W niniejszej pracy podsumowano proces starzenia się układu immunologicznego i wpływ stresu proliferacyjnego na wrodzoną i nabytą odpowiedź immunologiczną, której wykładnikiem są zjawiska immunosenescencji oraz inflammagingu, w kontekście jatrogennego stresu proliferacyjnego, indukowanego przez allo-HCT.

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Keywords

immunosenescencja; inflammaging; allo-HCT; stres proliferacyjny

About this article
Title

Wpływ stresu proliferacyjnego na nabytą i wrodzoną odpowiedź immunologiczną

Journal

Journal of Transfusion Medicine

Issue

Vol 16, No 2 (2023)

Article type

Review paper

Pages

97-102

Published online

2023-04-28

Page views

201

Article views/downloads

126

Bibliographic record

Journal of Transfusion Medicine 2023;16(2):97-102.

Keywords

immunosenescencja
inflammaging
allo-HCT
stres proliferacyjny

Authors

Michał Cezary Czarnogórski
Jacek M. Witkowski
Jan M. Zaucha

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