Tom 15, Nr 3 (2022)
Artykuł przeglądowy
Opublikowany online: 2022-09-28
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Żylna choroba zakrzepowo-zatorowa i leczenie przeciwzakrzepowe w COVID-19
Journal of Transfusion Medicine 2022;15(3):266-271.
Streszczenie
Szczególną cechą COVID-19, głównie o ciężkim przebiegu, jest zwiększona skłonność do występowania
epizodów żylnej choroby zakrzepowo-zatorowej (ŻChZZ). Dość często przybiera
ona postać izolowanej zatorowości płucnej i bywa przyczyną nagłego zgonu chorych. Epizody
ŻChZZ obserwowano pomimo standardowej profilaktyki przeciwzakrzepowej, dlatego zasadnicze
znaczenie w przebiegu COVCID-19 ma dobór właściwej dawki leków stosowanych w profilaktyce
i leczeniu ŻChZZ. Lekami z wyboru są heparyny drobnocząsteczkowe (HDCz). W wielu
randomizowanych badaniach klinicznych porównywano dawki profilaktyczne, pośrednie i lecznicze
HDCz stosowane w profilaktyce ŻChZZ u chorych, zależnie od ciężkości przebiegu choroby.
Niniejsze opracowanie przedstawia bieżące zalecenia grupy ekspertów International Society
on Thrombosis and Hememostasis na temat profilaktyki ŻChZZ w przebiegu COVID-19, które
powstały na podstawie wyników dostępnych obecnie badań klinicznych.
Słowa kluczowe: żylna choroba zakrzepowo-zatorowaCOVID-19leczenie przeciwzakrzepoweprofilaktyka przeciwzakrzepowaheparynyDOAC
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