open access

Vol 9, No 3 (2016)
Case report
Published online: 2016-11-22
Get Citation

A patient with undetected haemophilia C and recurrent bleedings during anticoagulant therapy

Magdalena Kaczmarek-Kowalska, Paweł Szczepaniec
Journal of Transfusion Medicine 2016;9(3):101-105.

open access

Vol 9, No 3 (2016)
CASE REPORTS
Published online: 2016-11-22

Abstract


Haemophilia C is an uncommon bleeding disorder caused by XI factor deficiency. The bleeding
intensity depends mainly on patient’s genotype, other coagulation factors activity and platelets
activity, less on XI factor activity so it is possible that asymptomatic illness reveals after anticoagulant
is administered.
The article describes a case of a patient with haemophilia C detected while she was being
diagnosed due to recurrent bleedings during rivaroxaban and vitamin K antagonist therapy.

Abstract


Haemophilia C is an uncommon bleeding disorder caused by XI factor deficiency. The bleeding
intensity depends mainly on patient’s genotype, other coagulation factors activity and platelets
activity, less on XI factor activity so it is possible that asymptomatic illness reveals after anticoagulant
is administered.
The article describes a case of a patient with haemophilia C detected while she was being
diagnosed due to recurrent bleedings during rivaroxaban and vitamin K antagonist therapy.

Get Citation

Keywords

haemophilia C; acenocoumarol; XI factor; rivaroxaban; bleeding disorder

About this article
Title

A patient with undetected haemophilia C and recurrent bleedings during anticoagulant therapy

Journal

Journal of Transfusion Medicine

Issue

Vol 9, No 3 (2016)

Article type

Case report

Pages

101-105

Published online

2016-11-22

Bibliographic record

Journal of Transfusion Medicine 2016;9(3):101-105.

Keywords

haemophilia C
acenocoumarol
XI factor
rivaroxaban
bleeding disorder

Authors

Magdalena Kaczmarek-Kowalska
Paweł Szczepaniec

References (10)
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  2. Bolton-Maggs PH. B. Factor XI deficiency and its management. Treatment of hemophilia. World Federation of Hemophilia, Montreal. 2008; 16: 1–14.
  3. Seligsohn U. Factor XI deficiency. J Thromb Haemost. 2009; 7(supl. 1): 84–87.
  4. Zawilska K, Chojnowski K, Klukowska A, et al. Polskie zalecenia postępowania w rzadkich niedoborach osoczowych czynników krzepnięcia. Hematologia. 2011; 2: 303–310.
  5. Bolton-Maggs PH. Factor XI deficiency--resolving the enigma? Hematology Am Soc Hematol Educ Program. 2009: 97–105.
  6. Myers B, Pavord S, Kean L, et al. Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency. BJOG. 2007; 114(5): 643–646.
  7. Franchini M, Manzato F, Salvagno GL, et al. The use of desmopressin in congenital factor XI deficiency: a systematic review. Ann Hematol. 2009; 88(10): 931–935.
  8. O’Connell N. Factor XI deficiency. Seminars in Hematology. 2004; 41: 76–81.
  9. Berliner S, Horowitz I, Martinowitz U, et al. Dental surgery in patients with severe factor XI deficiency without plasma replacement. Blood Coagul Fibrinolysis. 1992; 3(4): 465–468.
  10. Younis HS, Crosby J, Huh JI, et al. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood. 2012; 119(10): 2401–2408.

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