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Vol 9, No 3 (2016)
Review paper
Published online: 2016-11-22

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Diagnostic approach to type 2B von Willebrand disease

Ksenia Bykowska, Bernardeta Ceglarek
Journal of Transfusion Medicine 2016;9(3):87-100.


Type 2B Von Willebrand disease (VWD) is an inherited bleeding disorder with enhanced VWF
affinity to platelet glycoprotein Iba receptor. It results from mutation within 28 exon of von
Willebrand factor (VWF) that encodes the VWF A1 protein domain. As far as phenotype and
clinical symptoms are concerned 2B VWD resembles another type of bleeding disorder called
platelet-type von Willebrand disease (PT-VWD). In the course of the diagnostic procedure VWD
2B should always be differentation from PT-VWD. It should always be reckoned with in the
case of patients with thrombocytopenia.


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