open access

Vol 8, No 2 (2015)
Review paper
Published online: 2015-06-22
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mTOR signaling in pediatric acute lymphoblastic leukemia and its clinical consequences

Edyta Ulińska, Michał Matysiak
Journal of Transfusion Medicine 2015;8(2):43-48.

open access

Vol 8, No 2 (2015)
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Published online: 2015-06-22

Abstract

Extensive research has been conducted to identify more precise molecular and cytogenetic markers to improve risk stratification scheme and develop new targeted biological drugs in pediatric acute lymphoblastic leukemia (ALL). Activity of serine/threonine protein kinase mTOR plays a cardinal role in cell proliferation, differentiation, growth and survival. Dysregulation of mTOR signaling pathway is considered to be significant in the pathogenesis and clinical course of childhood ALL. Efficacy of mTOR inhibitors (MTI) in pediatric acute lymphoblastic leukemia has been evaluated in numerous studies. This review summarises the current knowledge of clinical relevance of mTOR signaling in childhood ALL and its potential therapeutic significance.

Abstract

Extensive research has been conducted to identify more precise molecular and cytogenetic markers to improve risk stratification scheme and develop new targeted biological drugs in pediatric acute lymphoblastic leukemia (ALL). Activity of serine/threonine protein kinase mTOR plays a cardinal role in cell proliferation, differentiation, growth and survival. Dysregulation of mTOR signaling pathway is considered to be significant in the pathogenesis and clinical course of childhood ALL. Efficacy of mTOR inhibitors (MTI) in pediatric acute lymphoblastic leukemia has been evaluated in numerous studies. This review summarises the current knowledge of clinical relevance of mTOR signaling in childhood ALL and its potential therapeutic significance.

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Keywords

mTOR, acute lymphoblastic leukemia, children, mTOR inhibitors

About this article
Title

mTOR signaling in pediatric acute lymphoblastic leukemia and its clinical consequences

Journal

Journal of Transfusion Medicine

Issue

Vol 8, No 2 (2015)

Article type

Review paper

Pages

43-48

Published online

2015-06-22

Bibliographic record

Journal of Transfusion Medicine 2015;8(2):43-48.

Keywords

mTOR
acute lymphoblastic leukemia
children
mTOR inhibitors

Authors

Edyta Ulińska
Michał Matysiak

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