Tom 7, Nr 3 (2014)
Artykuł przeglądowy
Opublikowany online: 2014-10-23
Wyświetlenia strony
1160
Wyświetlenia/pobrania artykułu
8733
Udział płytek krwi w procesach zapalnych
Journal of Transfusion Medicine 2014;7(3):102-109.
Streszczenie
Płytki krwi są postrzegane przede wszystkim jako komórki biorące udział w procesach hemostazy naczyniowej i utrzymaniu integralności ściany naczyniowej. Nie do końca znana jest natomiast ich rola w procesach zapalnych, które powiązane są z aktywnością wrodzonego układu odporności immunologicznej. W pracy zostaną omówione między innymi wydzielane z ziarnistości płytek krwi związki (cytokiny/chemokiny), które przy współudziale komórek śródbłonka rekrutują leukocyty do miejsca zapalenia, receptory TLR (Toll-like receptors) płytek uczestniczące w rozpoznawaniu obcego patogenu oraz zostaną opisane mechanizmy prowadzące do udziału płytek krwi w procesach zapalnych. Niniejsza praca ma na celu uproszczone przedstawienie wpływu płytek krwi na funkcjonowanie skomplikowanego systemu wrodzonej odpowiedzi immunologicznej.
Słowa kluczowe: płytki krwiprocesy zapalnecytokinyreceptory „Toll-like” płytek krwisystem odporności wrodzonej
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