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Vol 7, No 2 (2014)
Review paper
Published online: 2014-09-05

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The migration of hematopoietic cells and leukocytes

Joanna Kopeć-Szlęzak
Journal of Transfusion Medicine 2014;7(2):40-50.

Abstract

We discuss here the characteristics of migration processes of hematopoietic cells and leukocytes in physiology, inflammation or immune response. We present the principle elements of themigration process stimulated with granulocyte growth factor (G-CSF) during mobilization. Macrophages and nestin+ mesenchymal stem cells (MSC) are presented as key players in the hematopoietic G-CSF stimulated migration process (mobilization). The significant role of chemokine/receptor: CXC12/CXCR4 functional axis in bone marrow hematopoietic cells homingis emphasized. We next describe the leukocyte paracellular and/or transcellular transendothelial migration (TEM) as the critical step with cellular adhesion molecules (selectins, integrinsand CAM-s) and chemokine receptors activity. We also present characteristics of migration of specific cell lines: neutrofils, monocytes, macrophages, dendritic cells as well as T, B and NK lymphocytes. Finally, we present disorders in the migration of leukemia cells in some lymphoproliferative disorders (e.g. B cells in chronic lymphocytic leukemia).

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