open access

Vol 6, No 2 (2013)
Review paper
Get Citation

Proteomics and its application in selected diseases

Agata Płodzich
Journal of Transfusion Medicine 2013;6(2):48-59.

open access

Vol 6, No 2 (2013)
REVIEWS

Abstract

Proteomics is a branch of scientific research focused on the study of human proteome, i.e a genome-encoded protein component. The term “proteome” was coined and first used by Marc R. Wilkins in 1994. The principal aim of proteomic research is selection of cellular and organ- -produced proteins, in both physiological and pathological conditions and study of their threedimension structures and complex interactions. There are three main phases to proteomic studies : 1) collection and preliminary testing of biological material, 2) protein profile analysis3) final data analysis. Each phase relies on increasingly novel and advanced technologies therefore application of proteomic techniques in clinical practice provides the opportunity of identifying new biomarkers and novel therapeutic targets for use in diagnostics and treatment of oncological diseases. Furthermore, proteomic technologies applied in clinical practice allow for earlier diagnosis of disease, prognosis for treatment and patient’s response to treatment. Proteomic experiments involve several methodological challenges which may impede data interpretation and conclusions. A uniform set of standards seems therefore indispensible as it would allow the comparison of results from different laboratories whereas a uniform set of quality criteria would enable comparison of results obtained at each stage of analysis. Research on various biomarkers demonstrates that results of proteomic studies could then be successfully applied in clinical practice. The aim of this paper was to present the current achievements of proteomics on the examples of selected malignant tumors and the Down syndrome.

Abstract

Proteomics is a branch of scientific research focused on the study of human proteome, i.e a genome-encoded protein component. The term “proteome” was coined and first used by Marc R. Wilkins in 1994. The principal aim of proteomic research is selection of cellular and organ- -produced proteins, in both physiological and pathological conditions and study of their threedimension structures and complex interactions. There are three main phases to proteomic studies : 1) collection and preliminary testing of biological material, 2) protein profile analysis3) final data analysis. Each phase relies on increasingly novel and advanced technologies therefore application of proteomic techniques in clinical practice provides the opportunity of identifying new biomarkers and novel therapeutic targets for use in diagnostics and treatment of oncological diseases. Furthermore, proteomic technologies applied in clinical practice allow for earlier diagnosis of disease, prognosis for treatment and patient’s response to treatment. Proteomic experiments involve several methodological challenges which may impede data interpretation and conclusions. A uniform set of standards seems therefore indispensible as it would allow the comparison of results from different laboratories whereas a uniform set of quality criteria would enable comparison of results obtained at each stage of analysis. Research on various biomarkers demonstrates that results of proteomic studies could then be successfully applied in clinical practice. The aim of this paper was to present the current achievements of proteomics on the examples of selected malignant tumors and the Down syndrome.

Get Citation

Keywords

proteomics, proteome, posttranslational modifications, biomarkers, proteomic techniques, bioinformatics, clinical proteomics, oncological disorders, Down syndrome

About this article
Title

Proteomics and its application in selected diseases

Journal

Journal of Transfusion Medicine

Issue

Vol 6, No 2 (2013)

Article type

Review paper

Pages

48-59

Bibliographic record

Journal of Transfusion Medicine 2013;6(2):48-59.

Keywords

proteomics
proteome
posttranslational modifications
biomarkers
proteomic techniques
bioinformatics
clinical proteomics
oncological disorders
Down syndrome

Authors

Agata Płodzich

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Journal of Transfusion Medicine dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest Via Medica sp. z o.o. sp. komandytowa, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl