open access

Vol 1, No 1 (2008)
Research paper
Published online: 2009-02-02
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Is ALAT activity test helpful in eliminating viral hepatitis carriers from donor population?

Aleksandra Dzieciątkowska, Aleksandra Rosiek, Elżbieta Lachert, Jolanta Kubis, Magdalena Łętowska
Journal of Transfusion Medicine 2008;1(1):28-35.

open access

Vol 1, No 1 (2008)
ORIGINAL PAPERS
Published online: 2009-02-02

Abstract


Background: Alanine aminotransferase (AlAT) activity test is still one of the main liver function markers though its usefulness in routine testing of blood donors has been disputed by many scientists, especially after introducing more sensitive serological techniques and nucleic acid testing (NAT) for HBV and HCV detection. Following the introduction of these techniques, many countries eliminated AlAT activity from donor testing. In Poland however, AlAT testing is still performed for additional protection of recipients against potential infection with unknown hepatotropic viruses or transfusion of blood component from serological „window” donors.
Material and methods: HBV and HCV (HBsAg, anti-HCV, HCV-RIBA) and molecular biology testing (DNA HBV, RNA HCV) results as well as AlAT activity results for donors from all Polish regional blood transfusion centers (RBTC) in 2005 were collected and analyzed.
Results: It was determined that in most donors with serological markers and/or virus genetic material, the AlAT value was within normal range.
Conclusions: Therefore it seems advisable to consider eliminating AlAT testing for donors, especially now that NAT HBV and HCV is routinely performed.

Abstract


Background: Alanine aminotransferase (AlAT) activity test is still one of the main liver function markers though its usefulness in routine testing of blood donors has been disputed by many scientists, especially after introducing more sensitive serological techniques and nucleic acid testing (NAT) for HBV and HCV detection. Following the introduction of these techniques, many countries eliminated AlAT activity from donor testing. In Poland however, AlAT testing is still performed for additional protection of recipients against potential infection with unknown hepatotropic viruses or transfusion of blood component from serological „window” donors.
Material and methods: HBV and HCV (HBsAg, anti-HCV, HCV-RIBA) and molecular biology testing (DNA HBV, RNA HCV) results as well as AlAT activity results for donors from all Polish regional blood transfusion centers (RBTC) in 2005 were collected and analyzed.
Results: It was determined that in most donors with serological markers and/or virus genetic material, the AlAT value was within normal range.
Conclusions: Therefore it seems advisable to consider eliminating AlAT testing for donors, especially now that NAT HBV and HCV is routinely performed.
Get Citation

Keywords

alanine aminotransferase; virus hepatitis B and C; serological tests; molecular biology techniques/methods; nucleic acid testing

About this article
Title

Is ALAT activity test helpful in eliminating viral hepatitis carriers from donor population?

Journal

Journal of Transfusion Medicine

Issue

Vol 1, No 1 (2008)

Article type

Research paper

Pages

28-35

Published online

2009-02-02

Bibliographic record

Journal of Transfusion Medicine 2008;1(1):28-35.

Keywords

alanine aminotransferase
virus hepatitis B and C
serological tests
molecular biology techniques/methods
nucleic acid testing

Authors

Aleksandra Dzieciątkowska
Aleksandra Rosiek
Elżbieta Lachert
Jolanta Kubis
Magdalena Łętowska

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