Tom 3, Nr 1 (2010)
Artykuł przeglądowy
Opublikowany online: 2010-03-19
Wyświetlenia strony
582
Wyświetlenia/pobrania artykułu
3453
Fizjologiczna i patogenna aktywność mikrocząstek błon komórkowych
DOI: 10.5603/jtm.v3i1.28432
Journal of Transfusion Medicine 2010;3(1):9-18.
Streszczenie
Mikrocząstki (MP) są uwalniane z błon powierzchniowych większości komórek eukariotycznych.
W pracy przedstawiono, na podstawie doniesień literatury światowej, różne rodzaje aktywności
MP: prokoagulacyjną i antykoagulacyjną, efekt immunomodulacyjny, zdolność do adhezji i indukowania
procesów zapalnych, udział w apoptozie, angiogenezie i przyjęciu przeszczepów komórek
hematopoetycznych. Ponadto opisano wpływ MP na powstawanie wrodzonych zaburzeń czynności
płytek krwi, hemoglobinopatii S, małopłytkowości indukowanej heparyną, posocznicy, zakrzepowej
plamicy małopłytkowej, nocnej napadowej hemoglobinurii, cukrzycy, patologii w chorobach
sercowo-naczyniowych, w zakrzepicy żył głębokich oraz zatorach pęcherzyków płucnych. Zwrócono
także uwagę na znaczenie MP w składnikach krwi przygotowywanych do transfuzji.
Słowa kluczowe: fizjopatologia mikrocząstekaktywność mikrocząstekkliniczne znaczenie mikrocząstek
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