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Vol 3, No 2 (2010)
Review paper
Published online: 2010-06-02
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Differentiation of human peripheral blood monocytes

Joanna Kopeć-Szlęzak
Journal of Transfusion Medicine 2010;3(2):62-66.

open access

Vol 3, No 2 (2010)
REVIEWS
Published online: 2010-06-02

Abstract

Monocytes were defined 50 years ago. Monocytes are circulating cell precursors for tissue macrophages and dendritic cells. The monocyte functional and phenotype heterogeneity have been recognized and in the recent years investigators have identified two human major monocyte subsets CD14+CD16-CCR2+ (classic - about 90%) and CD14+CD16+CX3CR1+ (nonclassic - about 10%). Among monocytes there exist proangiogenic subsets with angiopeoetin- 2 receptor expression (CD202a+) cells and probably - potentially proliferating monocytes. In special environment monocytes may differentiate in osteoclasts and giant cells; recent experimental evidence highlights the “plasticity” of these cells.
J. Transf. Med. 2010; 2: 62-66

Abstract

Monocytes were defined 50 years ago. Monocytes are circulating cell precursors for tissue macrophages and dendritic cells. The monocyte functional and phenotype heterogeneity have been recognized and in the recent years investigators have identified two human major monocyte subsets CD14+CD16-CCR2+ (classic - about 90%) and CD14+CD16+CX3CR1+ (nonclassic - about 10%). Among monocytes there exist proangiogenic subsets with angiopeoetin- 2 receptor expression (CD202a+) cells and probably - potentially proliferating monocytes. In special environment monocytes may differentiate in osteoclasts and giant cells; recent experimental evidence highlights the “plasticity” of these cells.
J. Transf. Med. 2010; 2: 62-66
Get Citation

Keywords

monocytes; peripheral blood; subsets; differentiation

About this article
Title

Differentiation of human peripheral blood monocytes

Journal

Journal of Transfusion Medicine

Issue

Vol 3, No 2 (2010)

Article type

Review paper

Pages

62-66

Published online

2010-06-02

Bibliographic record

Journal of Transfusion Medicine 2010;3(2):62-66.

Keywords

monocytes
peripheral blood
subsets
differentiation

Authors

Joanna Kopeć-Szlęzak

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