open access

Vol 4, No 3 (2011)
Other materials agreed with the Editors
Published online: 2011-09-23
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Occult hepatitis B virus infection in Thai blood donors

Suda Louissirirotchanakul, Sineenart Oota, Kalayanee Khuponsarb, Wilai Chalermchan, Soisaang Phikulsod, Viroje Chongkolwatana, Tasanee Sakuldamrongpanish, Pimpun Kitpoka, Pimol Chielsilp, Srivilai Tanprasert, Thaweesak Tirawatnapong, Chantapong West oraz Grupa Robocza ds. B Krwiodawstwie
Journal of Transfusion Medicine 2011;4(3):143-154.

open access

Vol 4, No 3 (2011)
TRANSLATION
Published online: 2011-09-23

Abstract

Background: An evaluation by the National Blood Center, the Thai Red Cross Society, of two commercial multiplex nucleic acid tests (NATs; the Chiron PROCLEIX ULTRIO test and the Roche Cobas TaqScreen MPX test) for screening Thai blood donors for hepatitis B virus (HBV), hepatitis C virus, and human immunodeficiency virus Type 1 identified 175 HBV NAT–reactive/hepatitis B surface antigen (HBsAg)-negative donors. The classification of the HBV infection of these donors was confirmed by follow-up testing.
Study design and methods: Index samples were tested for HBV serologic markers and HBV viral loads were determined. Donors were followed for up to 13 months and samples were tested with both NAT assays and for all HBV serological markers.
Results: Of 175 HBV NAT-yield donors, 72 (41%) were followed. Based on the follow-up results, the majority of donors who were followed had an occult HBV infection (66.7%), followed by donors with a primary, acute infection (26.4%). The majority of donors in this latter group (20.8%) were in the window period. Three donors (4.2%), who were anti-HBs positive, had a reinfection or breakthrough infection.
Conclusion: The majority of donors detected during routine screening, who were HBsAg negative and NAT reactive, had an occult HBV infection, thus validating the decision to introduce NAT for blood donations in Thailand.
J. Transf. Med. 2011; 3: 143–154

Abstract

Background: An evaluation by the National Blood Center, the Thai Red Cross Society, of two commercial multiplex nucleic acid tests (NATs; the Chiron PROCLEIX ULTRIO test and the Roche Cobas TaqScreen MPX test) for screening Thai blood donors for hepatitis B virus (HBV), hepatitis C virus, and human immunodeficiency virus Type 1 identified 175 HBV NAT–reactive/hepatitis B surface antigen (HBsAg)-negative donors. The classification of the HBV infection of these donors was confirmed by follow-up testing.
Study design and methods: Index samples were tested for HBV serologic markers and HBV viral loads were determined. Donors were followed for up to 13 months and samples were tested with both NAT assays and for all HBV serological markers.
Results: Of 175 HBV NAT-yield donors, 72 (41%) were followed. Based on the follow-up results, the majority of donors who were followed had an occult HBV infection (66.7%), followed by donors with a primary, acute infection (26.4%). The majority of donors in this latter group (20.8%) were in the window period. Three donors (4.2%), who were anti-HBs positive, had a reinfection or breakthrough infection.
Conclusion: The majority of donors detected during routine screening, who were HBsAg negative and NAT reactive, had an occult HBV infection, thus validating the decision to introduce NAT for blood donations in Thailand.
J. Transf. Med. 2011; 3: 143–154
Get Citation
About this article
Title

Occult hepatitis B virus infection in Thai blood donors

Journal

Journal of Transfusion Medicine

Issue

Vol 4, No 3 (2011)

Article type

Other materials agreed with the Editors

Pages

143-154

Published online

2011-09-23

Bibliographic record

Journal of Transfusion Medicine 2011;4(3):143-154.

Authors

Suda Louissirirotchanakul
Sineenart Oota
Kalayanee Khuponsarb
Wilai Chalermchan
Soisaang Phikulsod
Viroje Chongkolwatana
Tasanee Sakuldamrongpanish
Pimpun Kitpoka
Pimol Chielsilp
Srivilai Tanprasert
Thaweesak Tirawatnapong
Chantapong West oraz Grupa Robocza ds. B Krwiodawstwie

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