open access

Vol 4, No 3 (2011)
Review paper
Published online: 2011-09-23
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Haematopoietic stem cell in bone marrow niche

Joanna Kopeć-Szlęzak
Journal of Transfusion Medicine 2011;4(3):129-135.

open access

Vol 4, No 3 (2011)
REVIEWS
Published online: 2011-09-23

Abstract

During postnatal life haematopoietic stem cells (HSCs) are localized in bone marrow niches. Interaction of HSCs with their niche is critical to sustaining the balance between quiescence and proliferating pool (osteoblastic niche) and between self renovation and differentiation processes (perivascular niche). In HSCs mobilization there is observed a disruption of the mechanisms that retain HSCs in their niche. G-CSF administration leads to destruction of the structure and function of osteoblasts and HSCs migrate to perivascular areas. Simultaneously G-CSF stimulates neutrophile protease release and complement activation; in effect HSCs migrate to blood stream. During transplantation HSCs migrate from blood stream to the bone marrow (“homing”) and next 3 to their niche (“lodgement”). The understanding of cellular and molecular mechanisms is beneficial in HSCs transplantation.
J. Transf. Med. 2011; 3: 129–135

Abstract

During postnatal life haematopoietic stem cells (HSCs) are localized in bone marrow niches. Interaction of HSCs with their niche is critical to sustaining the balance between quiescence and proliferating pool (osteoblastic niche) and between self renovation and differentiation processes (perivascular niche). In HSCs mobilization there is observed a disruption of the mechanisms that retain HSCs in their niche. G-CSF administration leads to destruction of the structure and function of osteoblasts and HSCs migrate to perivascular areas. Simultaneously G-CSF stimulates neutrophile protease release and complement activation; in effect HSCs migrate to blood stream. During transplantation HSCs migrate from blood stream to the bone marrow (“homing”) and next 3 to their niche (“lodgement”). The understanding of cellular and molecular mechanisms is beneficial in HSCs transplantation.
J. Transf. Med. 2011; 3: 129–135
Get Citation

Keywords

hematopietic stem/progenitor cells; bone marrow niche; mobilization; transplantation

About this article
Title

Haematopoietic stem cell in bone marrow niche

Journal

Journal of Transfusion Medicine

Issue

Vol 4, No 3 (2011)

Article type

Review paper

Pages

129-135

Published online

2011-09-23

Bibliographic record

Journal of Transfusion Medicine 2011;4(3):129-135.

Keywords

hematopietic stem/progenitor cells
bone marrow niche
mobilization
transplantation

Authors

Joanna Kopeć-Szlęzak

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