Vol 5, No 4 (2012)
Review paper
Published online: 2012-12-17
Czynniki wpływające na skuteczność ITI u chorych
Anna Klukowska
Journal of Transfusion Medicine 2012;5(4):171-175.
Vol 5, No 4 (2012)
REVIEWS
Published online: 2012-12-17
Abstract
Factor VIII (FVIII) inhibitor development is the most serious complication of haemophilic
patient treatment. An inhibitor occurs in about 10–52% of patients with haemophilia A. There
are different reasons of this situation. The most important among them are: type of FVIII
mutation, presence of inhibitor in the family and intensity of initial treatment with concentrates
of FVIII. The development of inhibitor causes lower efficacy of bleeding treatment, higher
cost of treatment, increased frequency of bleeding, more advanced haemophilic arthropathy
and lower quality of life. The eradication of inhibitor is very substantial goal in haemophiliac
treatment. Immune tolerance induction is the only proved way to remove inhibitor and to
continue successful treatment with FVIII concentrates.
Abstract
Factor VIII (FVIII) inhibitor development is the most serious complication of haemophilic
patient treatment. An inhibitor occurs in about 10–52% of patients with haemophilia A. There
are different reasons of this situation. The most important among them are: type of FVIII
mutation, presence of inhibitor in the family and intensity of initial treatment with concentrates
of FVIII. The development of inhibitor causes lower efficacy of bleeding treatment, higher
cost of treatment, increased frequency of bleeding, more advanced haemophilic arthropathy
and lower quality of life. The eradication of inhibitor is very substantial goal in haemophiliac
treatment. Immune tolerance induction is the only proved way to remove inhibitor and to
continue successful treatment with FVIII concentrates.
Keywords
haemophilia A; factor VIII inhibitor; immune tolerance induction
Title
Czynniki wpływające na skuteczność ITI u chorych
Journal
Journal of Transfusion Medicine
Issue
Vol 5, No 4 (2012)
Article type
Review paper
Pages
171-175
Published online
2012-12-17
Bibliographic record
Journal of Transfusion Medicine 2012;5(4):171-175.
Keywords
haemophilia A
factor VIII inhibitor
immune tolerance induction