open access
Praziquantel as the preferred treatment for schistosomiasis
, 1, 1, 1, 1, 1
Affiliations- Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
open access
Abstract
Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health challenge.
This review offers a thorough examination of the disease’s epidemiology, transmission dynamics, diagnostic
modalities, and treatment options. Diagnostic techniques encompass direct parasitological methods,
immunological assays, DNA/RNA detection, and biomarker utilization, each with distinct advantages and limitations.
There is an urgent need for improved diagnostic tools with enhanced sensitivity and specificity.
Praziquantel remains the cornerstone of treatment, exhibiting efficacy against all Schistosoma species,
while the potential of artemisin derivatives in combination therapy is also explored. In this review, we focus
on the importance of praziquantel administration as the central aspect of schistosomiasis treatment,
highlighting ongoing efforts to optimize its utilization for improved patient outcomes.
Abstract
Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health challenge.
This review offers a thorough examination of the disease’s epidemiology, transmission dynamics, diagnostic
modalities, and treatment options. Diagnostic techniques encompass direct parasitological methods,
immunological assays, DNA/RNA detection, and biomarker utilization, each with distinct advantages and limitations.
There is an urgent need for improved diagnostic tools with enhanced sensitivity and specificity.
Praziquantel remains the cornerstone of treatment, exhibiting efficacy against all Schistosoma species,
while the potential of artemisin derivatives in combination therapy is also explored. In this review, we focus
on the importance of praziquantel administration as the central aspect of schistosomiasis treatment,
highlighting ongoing efforts to optimize its utilization for improved patient outcomes.
Keywords
schistosomiasis; schistosome; praziquantel
About this articleTitle
Praziquantel as the preferred treatment for schistosomiasis
Journal
Issue
Article type
Review article
Pages
49-54
Published online
2024-03-29
Page views
76
Article views/downloads
50
DOI
10.5603/imh.99453
Pubmed
Bibliographic record
IMH 2024;75(1):49-54.
Keywords
schistosomiasis
schistosome
praziquantel
Authors
Yusuf Haz Condeng
Sudirman Katu
Andi Makbul Aman
Haerani Rasyid
Syakib Bakri
Harun Iskandar
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