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Assessment of plasma malondialdehyde levels among free-diver fishermen in southeast Maluku district: exploring influencing factors on oxidative stress
Affiliations- Faculty of Medicine, University of Pattimura, Ambon, Indonesia
- Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
- Molecular Biology and Proteomic Core Facility, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
open access
Abstract
Background: Indonesia, with its expansive territorial waters, hosts numerous fishing communities residing
on various islands. Many of these communities rely on diving activities, predominantly free diving without
standardized safety equipment. This practice poses risks, including the potential for hypoxia-induced
oxidative stress, which plays a role in disease pathogenesis. This study aimed to investigate the levels
of malondialdehyde (MDA) in freediving fishermen and explore potential influencing factors.
Materials and methods: The research involved 30 freediving fishermen, aged 20–60, who engaged in diving
at least twice weekly over the last 3 months. Blood plasma MDA levels were assessed using the Will method.
Results: Results revealed a median age of 40.5 years (range: 20–59), a body mass index of 23.1 ± 2.8,
and a mean blood pressure of 132/85 mmHg. A significant portion of the subjects exhibited smoking
habits (90%) and alcohol consumption (76.7%). The median MDA level among subjects was measured
at 0.42 nmol/mL (range: 0.34–0.70). However, no discernible relationship was found between smoking
habits, alcohol consumption, and MDA level categories, as determined by the Fisher exact test (p > 0.05).
Conclusions: While these findings shed light on the MDA levels in freediving fishermen, further research is
warranted to explore additional factors that may influence these levels. This comprehensive understanding
is crucial for addressing the health risks associated with free diving practices in this unique population.
Abstract
Background: Indonesia, with its expansive territorial waters, hosts numerous fishing communities residing
on various islands. Many of these communities rely on diving activities, predominantly free diving without
standardized safety equipment. This practice poses risks, including the potential for hypoxia-induced
oxidative stress, which plays a role in disease pathogenesis. This study aimed to investigate the levels
of malondialdehyde (MDA) in freediving fishermen and explore potential influencing factors.
Materials and methods: The research involved 30 freediving fishermen, aged 20–60, who engaged in diving
at least twice weekly over the last 3 months. Blood plasma MDA levels were assessed using the Will method.
Results: Results revealed a median age of 40.5 years (range: 20–59), a body mass index of 23.1 ± 2.8,
and a mean blood pressure of 132/85 mmHg. A significant portion of the subjects exhibited smoking
habits (90%) and alcohol consumption (76.7%). The median MDA level among subjects was measured
at 0.42 nmol/mL (range: 0.34–0.70). However, no discernible relationship was found between smoking
habits, alcohol consumption, and MDA level categories, as determined by the Fisher exact test (p > 0.05).
Conclusions: While these findings shed light on the MDA levels in freediving fishermen, further research is
warranted to explore additional factors that may influence these levels. This comprehensive understanding
is crucial for addressing the health risks associated with free diving practices in this unique population.
Keywords
malondialdehyde (MDA); Will’s; smoking; alcohol; hypoxia
About this articleTitle
Assessment of plasma malondialdehyde levels among free-diver fishermen in southeast Maluku district: exploring influencing factors on oxidative stress
Journal
Issue
Article type
Original article
Pages
29-34
Published online
2024-03-29
Page views
62
Article views/downloads
30
DOI
10.5603/imh.98459
Pubmed
Bibliographic record
IMH 2024;75(1):29-34.
Keywords
malondialdehyde (MDA)
Will’s
smoking
alcohol
hypoxia
Authors
Sulfiana Sulfiana
Filda Vionita Irene de Lima
Eka Astuty
Novi SIlvia Hardiany
Febriana Catur Iswanti
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