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Published online: 2022-10-27
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Diagnostic accuracy of serum human epididymis protein 4 in ovarian cancer patients with different ethnic groups and menopausal status: a meta-analysis and systematic evaluation

Rui Sun1, Lin Liu2, Zhengli Feng1, Ao Ni3, Qing Guo1
DOI: 10.5603/GP.a2022.0128
·
Pubmed: 36378126
Affiliations
  1. Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China, China
  2. Dalian Hunter Information Consulting Co. LTD, China
  3. FuNing People's Hospital, China

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Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2022-10-27

Abstract

Objectives: We aimed to analyze and evaluate the diagnostic value of serum human epididymis protein 4 (HE4) in ovarian cancer (OC) of patients with different menopausal status.

Material and methods: A comprehensive electronic and manual search of the relevant literature was performed through several databases such as CNKI, Wanfang database, VIP database, Chinese biomedical database, web of science, PubMed, EMBASE, and Cochrane database. We collected Chinese and English articles to assess the diagnostic value of HE4 for ovarian cancer in female with different menopausal status. The quality of the studies included in the systematic review was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool.

Results: A total of 14 publications were included in this study and we didn’t find publication bias in them. The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of HE4 for the diagnosis of ovarian cancer in postmenopausal vs. premenopausal female were 0.71 (95% CI, 0.63–0.78) vs 0.78 (95% CI, 0.74–0.81); 0.91 (95% CI, 0.85–0.95) vs 0.90 (95% CI, 0.86–0.93); 11.90 (95% CI, 6.42–22.07) vs 11.03 (95% CI, 6.44–18.89); and 0.30 (95% CI, 0.22–0.39) vs 0.24 (95% CI, 0.20–0.29), respectively.

Conclusions: Serum HE4 has greater diagnostic value in detecting ovarian cancer, especially in Asian postmenopausal female.

Abstract

Objectives: We aimed to analyze and evaluate the diagnostic value of serum human epididymis protein 4 (HE4) in ovarian cancer (OC) of patients with different menopausal status.

Material and methods: A comprehensive electronic and manual search of the relevant literature was performed through several databases such as CNKI, Wanfang database, VIP database, Chinese biomedical database, web of science, PubMed, EMBASE, and Cochrane database. We collected Chinese and English articles to assess the diagnostic value of HE4 for ovarian cancer in female with different menopausal status. The quality of the studies included in the systematic review was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool.

Results: A total of 14 publications were included in this study and we didn’t find publication bias in them. The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of HE4 for the diagnosis of ovarian cancer in postmenopausal vs. premenopausal female were 0.71 (95% CI, 0.63–0.78) vs 0.78 (95% CI, 0.74–0.81); 0.91 (95% CI, 0.85–0.95) vs 0.90 (95% CI, 0.86–0.93); 11.90 (95% CI, 6.42–22.07) vs 11.03 (95% CI, 6.44–18.89); and 0.30 (95% CI, 0.22–0.39) vs 0.24 (95% CI, 0.20–0.29), respectively.

Conclusions: Serum HE4 has greater diagnostic value in detecting ovarian cancer, especially in Asian postmenopausal female.

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Keywords

ovarian cancer; meta-analysis; HE4; tumor markers; diagnosis

About this article
Title

Diagnostic accuracy of serum human epididymis protein 4 in ovarian cancer patients with different ethnic groups and menopausal status: a meta-analysis and systematic evaluation

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2022-10-27

Page views

557

Article views/downloads

320

DOI

10.5603/GP.a2022.0128

Pubmed

36378126

Keywords

ovarian cancer
meta-analysis
HE4
tumor markers
diagnosis

Authors

Rui Sun
Lin Liu
Zhengli Feng
Ao Ni
Qing Guo

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