Vol 92, No 7 (2021)
Review paper
Published online: 2021-05-13

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The role of anti-Müllerian Hormone (AMH) in girls and adolescents

Iwona J. Czech1, Agnieszka Drosdzol-Cop1
Pubmed: 34105756
Ginekol Pol 2021;92(7):525-527.

Abstract

Anti-mullerian hormone (AMH) is produced by the granular cells of primary, preantral and antral follicles. The circulating levels of AMH in adult women reflect the number of remaining primordial follicles. AMH determination plays an increasingly important role in diagnostics in endocrinology and gynecology in adult women. Although the determination of AMH levels is used in pediatric practice, still little is known about its role in various pubertal disorders in girls. This article presents the clinical use of AMH in girls and adolescents.

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References

  1. Rajpert-De Meyts E, Jørgensen N, Graem N, et al. Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab. 1999; 84(10): 3836–3844.
  2. Wikarek T, Olszanecka-Glinianowicz M, Chudek J, et al. Hormon anty-Müllerowski a zaburzenia płodności u otyłych kobiet i kobiet z zespołem policystycznych jajników. Ginekol Pol. 2011; 82(3): 205–209.
  3. Bręborowicz G. Położnictwo i ginekologia. PZWL, Warszawa 2015.
  4. Krawczyńska M, Słowińska-Srzednicka J. Zastosowanie oznaczeń stężeń hormonu antymüllerowskiego (AMH) w diagnostyce chorób endokrynnych. Borgis - Postępy Nauk Medycznych. 2016; 12: 921–928.
  5. Behringer RR, Finegold MJ, Cate RL. Müllerian-inhibiting substance function during mammalian sexual development. Cell. 1994; 79(3): 415–425.
  6. Lukaszuk K, Ludwikowska B, Liss J, et al. Decreasing quality of the new generations of anti-Müllerian hormone assays. Biomed Res Int. 2014; 2014: 165352.
  7. Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014; 20(3): 370–385.
  8. Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online. 2016; 33(1): 15–28.
  9. Kruszyńska A, Słowińska-Srzednicka J. Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Prz Menopauzalny. 2017; 16(2): 47–50.
  10. Dewailly D, Pigny P, Soudan B, et al. Reconciling the definitions of polycystic ovary syndrome: the ovarian follicle number and serum anti-Müllerian hormone concentrations aggregate with the markers of hyperandrogenism. J Clin Endocrinol Metab. 2010; 95(9): 4399–4405.
  11. Dębski R, Kruszyńska A. Diagnostyka endokrynologiczna w ginekologii. In: Zgliczyński W, Kruszyńska A. ed. Wielka interna - endokrynologia, wyd. II. Medical Tribune Polska, Warszawa 2020.
  12. Hagen CP, Aksglaede L, Sørensen K, et al. Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients. J Clin Endocrinol Metab. 2010; 95(11): 5003–5010.
  13. Codner E, Iñiguez G, Hernández IM, et al. Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus. Clin Endocrinol (Oxf). 2011; 74(1): 73–78.
  14. Hagen CP, Aksglaede L, Sørensen K, et al. Individual serum levels of anti-Müllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study. Hum Reprod. 2012; 27(3): 861–866.
  15. de Vet A, Laven JSE, de Jong FH, et al. Antimüllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril. 2002; 77(2): 357–362.
  16. Lashen H, Dunger DB, Ness A, et al. Peripubertal changes in circulating antimüllerian hormone levels in girls. Fertil Steril. 2013; 99(7): 2071–2075.
  17. Chen T, Wu H, Xie R, et al. Serum Anti-Müllerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls. J Pediatr Adolesc Gynecol. 2017; 30(3): 362–366.
  18. Xue J, Song W, Si M, et al. Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression. Int J Endocrinol. 2020; 2020: 3126309.
  19. Kim JY, Tfayli H, Michaliszyn SF, et al. Anti-Müllerian hormone in obese adolescent girls with polycystic ovary syndrome. J Adolesc Health. 2017; 60(3): 333–339.
  20. Efthymiadou A, Bogiatzidou M, Kritikou D, et al. Anti-Müllerian hormone in girls with premature adrenarche: the impact of polycystic ovary syndrome history in their mothers. J Pediatr. 2019; 205: 190–194.
  21. Lindhardt Johansen M, Hagen CP, Johannsen TH, et al. Anti-müllerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development. Int J Endocrinol. 2013; 2013: 198698.