Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Ginekologia Polska
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Reviewers 2023

open access

Vol 92, No 7 (2021)
Review paper
Published online: 2021-05-07
View PDF Download PDF file
Get Citation

Fresh insight into premature ovarian insufficiency

Paula Karska1, Aleksandra Matonog1, Paulina Sieradzka1, Karolina Kowalczyk1, Pawel Madej1
DOI: 10.5603/GP.a2021.0111
·
Pubmed: 34105755
·
Ginekol Pol 2021;92(7):518-524.
Affiliations
  1. Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

open access

Vol 92, No 7 (2021)
REVIEW PAPERS Gynecology
Published online: 2021-05-07

Abstract

Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers, such as interleukin-17 (IL-17), Frizzled-5 protein, Soggy-1 protein and other cytokines. Additionally, environmental toxicants such as chemicals and heavy metals might be relevant in the near future when investigating the causes of premature ovarian insufficiency. One of the main aims of the therapy is to focus on maintaining fertility among women with POI, since it is essential for patients considering their young age. Among the newest approaches listed there are different types of stem cells, oocytes donation and in-vitro activation, all of which are recently gaining in importance.

Abstract

Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers, such as interleukin-17 (IL-17), Frizzled-5 protein, Soggy-1 protein and other cytokines. Additionally, environmental toxicants such as chemicals and heavy metals might be relevant in the near future when investigating the causes of premature ovarian insufficiency. One of the main aims of the therapy is to focus on maintaining fertility among women with POI, since it is essential for patients considering their young age. Among the newest approaches listed there are different types of stem cells, oocytes donation and in-vitro activation, all of which are recently gaining in importance.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

premature ovarian insufficiency; premature ovarian failure; menopause; cytokines; hormone replacemet therapy; infertility; oncofertility

About this article
Title

Fresh insight into premature ovarian insufficiency

Journal

Ginekologia Polska

Issue

Vol 92, No 7 (2021)

Article type

Review paper

Pages

518-524

Published online

2021-05-07

Page views

1847

Article views/downloads

1890

DOI

10.5603/GP.a2021.0111

Pubmed

34105755

Bibliographic record

Ginekol Pol 2021;92(7):518-524.

Keywords

premature ovarian insufficiency
premature ovarian failure
menopause
cytokines
hormone replacemet therapy
infertility
oncofertility

Authors

Paula Karska
Aleksandra Matonog
Paulina Sieradzka
Karolina Kowalczyk
Pawel Madej

References (30)
  1. Rudnicka E, Kruszewska J, Klicka K, et al. Premature ovarian insufficiency - aetiopathology, epidemiology, and diagnostic evaluation. Prz Menopauzalny. 2018; 17(3): 105–108.
    CrossRefPubMed
  2. Wu X, Cai H, Kallianpur A, et al. Impact of premature ovarian failure on mortality and morbidity among Chinese women. PLoS One. 2014; 9(3): e89597.
    CrossRefPubMed
  3. Lagergren K, Hammar M, Nedstrand E, et al. The prevalence of primary ovarian insufficiency in Sweden; a national register study. BMC Womens Health. 2018; 18(1): 175.
    CrossRefPubMed
  4. Gruber N, Kugler S, de Vries L, et al. Primary ovarian insufficiency nationwide incidence rate and etiology among Israeli adolescents. J Adolesc Health. 2020; 66(5): 603–609.
    CrossRefPubMed
  5. Webber L, Davies M, Anderson R, et al. European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5): 926–937.
    CrossRefPubMed
  6. França MM, Mendonca BB. Genetics of primary ovarian insufficiency in the next-generation sequencing era. J Endocr Soc. 2020; 4(2): bvz037.
    CrossRefPubMed
  7. Qin Y, Jiao X, Simpson JL, et al. Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update. 2015; 21(6): 787–808.
    CrossRefPubMed
  8. Hoyos LR, Thakur M. Fragile X premutation in women: recognizing the health challenges beyond primary ovarian insufficiency. J Assist Reprod Genet. 2017; 34(3): 315–323.
    CrossRefPubMed
  9. He WB, Tan C, Zhang YX, et al. Homozygous variants in cause premature ovarian insufficiency. J Med Genet. 2021; 58(3): 168–172.
    CrossRefPubMed
  10. Alavi A, Darki F, Bidgoli MM, et al. Mutation in ALOX12B likely cause of POI and also ichthyosis in a large Iranian pedigree. Mol Genet Genomics. 2020; 295(4): 1039–1053.
    CrossRefPubMed
  11. Renault L, Patiño LC, Magnin F, et al. BMPR1A and BMPR1B missense mutations cause primary ovarian insufficiency. J Clin Endocrinol Metab. 2020; 105(4): dgz226.
    CrossRefPubMed
  12. Yang Y, Guo T, Liu R, et al. FANCL gene mutations in premature ovarian insufficiency. Hum Mutat. 2020; 41(5): 1033–1041.
    CrossRefPubMed
  13. Domniz N, Meirow D. Premature ovarian insufficiency and autoimmune diseases. Best Pract Res Clin Obstet Gynaecol. 2019; 60: 42–55.
    CrossRefPubMed
  14. Welt CK, Shapiro CL. Ovarian failure due to anticancer drugs and radiation. UpToDate. https://www.uptodate.com/contents/ovarian-failure-due-to-anticancer-drugs-and-radiation?search=premature ovarian insufficiency&topicRef=7435&source=see_link#H465437487 (2020-05-21).
  15. Cosgrove CM, Salani R. Ovarian effects of radiation and cytotoxic chemotherapy damage. Best Pract Res Clin Obstet Gynaecol. 2019; 55: 37–48.
    CrossRefPubMed
  16. Monteiro Cd, Xavier EB, Caetano JP, et al. A critical analysis of the impact of endocrine disruptors as a possible etiology of primary ovarian insufficiency. JBRA Assist Reprod. 2020; 24(3): 324–331.
    CrossRefPubMed
  17. Łukaszuk K, Kozioł K, Jakiel G, et al. Diagnostyka i leczenie niepłodności — rekomendacje Polskiego Towarzystwa Medycyny Rozrodu i Embriologii (PTMRiE) oraz Polskiego Towarzystwa Ginekologów i Położników (PTGP). Ginekol i Perinatol Prakt. 2018; 3(3): 112–140.
  18. Fraison E, Crawford G, Casper G, et al. Pregnancy following diagnosis of premature ovarian insufficiency: a systematic review. Reprod Biomed Online. 2019; 39(3): 467–476.
    CrossRefPubMed
  19. Michala L, Stefanaki K, Loutradis D. Premature ovarian insufficiency in adolescence: a chance for early diagnosis? Hormones (Athens). 2020; 19(3): 277–283.
    CrossRefPubMed
  20. Liu J, Huang X, Cao X, et al. Serum biomarker analysis in patients with premature ovarian insufficiency. Cytokine. 2020; 126: 154876.
    CrossRefPubMed
  21. Hamoda H. British Menopause Society and Women’s Health Concern. The British Menopause Society and Women's Health Concern recommendations on the management of women with premature ovarian insufficiency. Post Reprod Health. 2017; 23(1): 22–35.
    CrossRefPubMed
  22. Committee Opinion No. 698 Summary: Hormone Therapy in Primary Ovarian Insufficiency. Obstet Gynecol. 2017; 129(5): 963–964.
    CrossRefPubMed
  23. Webber L, Anderson RA, Davies M, et al. HRT for women with premature ovarian insufficiency: a comprehensive review. Hum Reprod Open. 2017; 2017(2): hox007.
    CrossRefPubMed
  24. Sheikhansari G, Aghebati-Maleki L, Nouri M, et al. Current approaches for the treatment of premature ovarian failure with stem cell therapy. Biomed Pharmacother. 2018; 102: 254–262.
    CrossRefPubMed
  25. Bidet M, Bachelot A, Bissauge E, et al. Resumption of ovarian function and pregnancies in 358 patients with premature ovarian failure. J Clin Endocrinol Metab. 2011; 96(12): 3864–3872.
    CrossRefPubMed
  26. Guideline of the European Society of Human Reproduction and Embryology. Management of women with premature ovarian insufficiency. POI Guideline Development Group. 2015: 54–62.
  27. Kawamura K, Kawamura N, Hsueh AJW. Activation of dormant follicles: a new treatment for premature ovarian failure? Curr Opin Obstet Gynecol. 2016; 28(3): 217–222.
    CrossRefPubMed
  28. Suzuki N, Yoshioka N, Takae S, et al. Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. Hum Reprod. 2015; 30(3): 608–615.
    CrossRefPubMed
  29. Chan JL, Wang ET. Oncofertility for women with gynecologic malignancies. Gynecol Oncol. 2017; 144(3): 631–636.
    CrossRefPubMed
  30. Takai Y. Recent advances in oncofertility care worldwide and in Japan. Reprod Med Biol. 2018; 17(4): 356–368.
    CrossRefPubMed

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl