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Published online: 2021-08-03
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Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis

Jian-qing Wang1, Jia-miao Zhang2, Bin Qian1
DOI: 10.5603/GP.a2021.0081
·
Pubmed: 34541648


Affiliations

  1. Department of Obstetrics and Gynecology, Yancheng Clinical College of Xuzhou Medical University, The First people's Hospital of Yancheng, Yancheng, China
  2. Department of Anesthesiology, Yancheng Clinical College of Xuzhou Medical University, The First people's Hospital of Yancheng, Yancheng, China

open access

Ahead of Print
ORIGINAL PAPERS Obstetrics
Published online: 2021-08-03

Abstract

Objectives: This study aimed at assessing the adverse outcomes of pregnancy in women with endometriosis.

Material and methods: The Cochrane, Embase and PubMed databases were searched for identifying the required studies published before June 2019. Meta-analyses of relative risk (RR) were performed under the random-effects model to estimate the risk of selected adverse outcomes of pregnancy in females with endometriosis.

Results: Twenty-eight studies (53,141 women with and 2,355,923 women without endometriosis data) were selected for meta-analysis. Endometriosis bearing females had a significantly higher risk placenta previa (RR 3.92 [95% CI 2.48–6.20]), miscarriage (RR 1.31 [95% CI 1.06–1.61), gestational hypertension (RR 1.30 [95% CI 1.02–1.65]), cesarean section (RR 1.48 [95% CI 1.33–1.65]) and preeclampsia (RR 1.18 [95% CI 1.09–1.28]). The incidence of placental abruption was not statistically significant between the groups (RR 3.62 [95% CI [0.99–13.28]).

Conclusions: Women suffering from endometriosis are at higher risks of miscarriage, preterm birth, gestational hypertension, placenta previa, cesarean section, and preeclampsia.

Abstract

Objectives: This study aimed at assessing the adverse outcomes of pregnancy in women with endometriosis.

Material and methods: The Cochrane, Embase and PubMed databases were searched for identifying the required studies published before June 2019. Meta-analyses of relative risk (RR) were performed under the random-effects model to estimate the risk of selected adverse outcomes of pregnancy in females with endometriosis.

Results: Twenty-eight studies (53,141 women with and 2,355,923 women without endometriosis data) were selected for meta-analysis. Endometriosis bearing females had a significantly higher risk placenta previa (RR 3.92 [95% CI 2.48–6.20]), miscarriage (RR 1.31 [95% CI 1.06–1.61), gestational hypertension (RR 1.30 [95% CI 1.02–1.65]), cesarean section (RR 1.48 [95% CI 1.33–1.65]) and preeclampsia (RR 1.18 [95% CI 1.09–1.28]). The incidence of placental abruption was not statistically significant between the groups (RR 3.62 [95% CI [0.99–13.28]).

Conclusions: Women suffering from endometriosis are at higher risks of miscarriage, preterm birth, gestational hypertension, placenta previa, cesarean section, and preeclampsia.

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Keywords

endometriosis; meta-analysis; pregnancy outcome  

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About this article
Title

Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-08-03

DOI

10.5603/GP.a2021.0081

Pubmed

34541648

Keywords

endometriosis
meta-analysis
pregnancy outcome  

Authors

Jian-qing Wang
Jia-miao Zhang
Bin Qian

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