Vol 95, No 2 (2024)
Clinical vignette
Published online: 2023-08-29

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Pazopanib-induced regression of metastatic cardiac tumor from uterine leiomyosarcoma evaluated by cardiac computed tomography

Shu Yoshihara1
Pubmed: 37642247
Ginekol Pol 2024;95(2):169-170.

Abstract

Not available

CLINICAL VIGNETTE

Ginekologia Polska

2024, vol. 95, no. 2, 167–168

Copyright © 2024 PTGiP

ISSN 0017–0011, e-ISSN 2543–6767

DOI: 10.5603/gpl.93941

Pazopanib-induced regression of metastatic cardiac tumor from uterine leiomyosarcoma evaluated by cardiac computed tomography

Shu Yoshihara
Departments of Diagnostic Radiology, Iwata City Hospital, Iwata, Japan

Corresponding author:

Shu Yoshihara

Department of Diagnostic Radiology, Iwata City Hospital, 512-3 Ookubo, Iwata, 438-8550, Japan

tel.: +81-538-38-5000, fax: +81-538-38-5052, e-mail: shuy@hospital.iwata.shizuoka.jp

Received: 31.01.2023 Accepted: 19.06.2023 Early publication date: 29.08.2023

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

A woman in her seventies with a large uterine mass underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. The pathological diagnosis was uterine leiomyosarcoma (ULMS) (Fig. S1). She presented with transient syncope 2 months after surgery. Transthoracic echocardiography showed an intracardiac mass extending from the right ventricle (RV) to the main pulmonary artery (PA) (Fig. S2A, B). Electrocardiography-gated cardiac computed tomography (CCT) demonstrated a mass of 33 mm by 23 mm in diameter involving the right ventricular wall with a highly mobile pedunculated acinous component that extended through the pulmonary valve into the PA, resulting in multiple pulmonary embolism (Fig. 1A, B). Cardiac and lung metastasis of ULMS was diagnosed. Pazopanib administration at 400 mg/day was started. Cardiac computed tomography re-examination 6 weeks after pazopanib treatment showed prominent regression of cardiac and lung metastasis (Fig. 1C, D). The right ventricular mass was 17 mm by 9 mm in diameter. Cardiac and lung metastasis regression continued after five months of pazopanib treatment, but gradually enlarged afterward. After eight months of treatment, pazopanib administration was discontinued because of disease progression. The patient died four months after cessation of pazopanib.

Figure 1A, B. Electrocardiography-gated cardiac computed tomography (A. Axial view; B. Coronal view) before pazopanib treatment showing a mass involving the right ventricular wall (arrows) with a pedunculated component (red arrowheads) that extended into the pulmonary artery (PA). White arrowheads indicate the right lung metastasis of the uterine leiomyosarcoma; C, D. Electrocardiography-gated cardiac computed tomography (C. Axial view; D. Coronal view) 6 weeks after pazopanib treatment; Aao ascending aorta; LA left atrium; LV left ventricle; RA right atrium; RV right ventricle

Uterine leiomyosarcoma is a rare tumor subtype that accounts for approximately 1% to 2% of all uterine malignancies. Compared with other types of uterine malignancies, ULMS is a biologically aggressive tumor, as evidenced by high rates of progression, recurrence, and mortality. Uterine leiomyosarcoma favors vascular invasion and has a high propensity for hematogenous spread, most commonly to the lungs. However, metastasis to the heart is rare. The only treatment effective for ULMS is complete early resection. Chemotherapy plays a major role in managing unresectable, advanced, or recurrent ULMS. Pazopanib is an orally active multi-targeted tyrosine kinase inhibitor of vascular endothelial growth factor receptors, platelet-derived growth factor receptors and stem cell factor receptors, thereby blocking angiogenesis and thus inhibiting subsequent tumor growth. Pazopanib has been tested in patients with metastatic non-adipocytic soft-tissue sarcoma after failure of standard chemotherapy and was shown to prolong median progression-free survival by three months relative to placebo [1]. In 2012 the Food and Drug Administration approved pazopanib for treating advanced soft-tissue sarcoma in patients failing prior chemotherapy. Previous reports have shown the clinically relevant efficacy of pazopanib with metastatic ULMS, but did not include patients with cardiac metastasis [2]. Therefore, its efficacy for cardiac metastasis of ULMS is unknown. Compared with tumors in other organs, cardiac tumors are difficult to measure precisely by non-electrocardiography-gated contrast-enhanced computed tomography due to cardiac motion artifacts. Delineation of the whole extent of cardiac tumors is difficult with echocardiography due to the limited echo angles, making it difficult to evaluate drug-induced cardiac tumor size reduction. In contrast, CCT can visualize the whole extent of intracardiac masses with few cardiac motion artifacts and few dead angles. In this case, we could examine CCT before and after pazopanib monotherapy and demonstrate obvious cardiac tumor regression. This is the first report to clearly show the effectiveness of pazopanib in a cardiac metastatic lesion of ULMS.

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Conflict of interest

Author declares no conflict of interest.

Supplementary material

Figures S1, S2 (available on https://journals.viamedica.pl/ginekologia_polska/article/view/93941).

REFERENCES

  1. van der Graaf WTA, Blay JY, Chawla SP, et al. EORTC Soft Tissue and Bone Sarcoma Group, PALETTE study group. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012; 379(9829): 18791886, doi: 10.1016/S0140-6736(12)60651-5, indexed in Pubmed: 22595799.
  2. Kim HJ, Kim Y, Lee SuJ, et al. Pazopanib monotherapy in the treatment of pretreated, metastatic uterine sarcoma: a single-center retrospective study. J Gynecol Oncol. 2018; 29(1): e3, doi: 10.3802/jgo.2018.29.e3, indexed in Pubmed: 29185261.