Tom 8, Nr 3-4 (2023)
Artykuł przeglądowy
Opublikowany online: 2024-03-15
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Odmienności funkcjonowania układu renina–angiotensyna–aldosteron w ciąży
1, 1
Ginekologia i Perinatologia Praktyczna 2023;8(3-4):156-162.
Streszczenie
Układ renina–angiotensyna–aldosteron (RAAS) jest jednym z najważniejszych systemów utrzymujących ciśnienie krwi i równowagę wodno-elektrolitową. Szereg zachodzących w nim w trakcie ciąży zmian pozwala na prawidłową implantację, rozwój łożyska oraz utrzymanie przepływu maciczno-łożyskowego. Większość elementów układu wykazuje w ciąży zwiększoną ekspresję, układ krwionośny pozostaje jednak oporny na działanie wazokonstrykcyjne RAAS. Dysregulacja RAAS oraz obecność przeciwciał przeciwko receptorom angiotensyny typu 1 odgrywają istotną rolę w patogenezie stanu przedrzucawkowego, indukując nadwrażliwość na angiotensynę II.
Słowa kluczowe: reninaangiotensynaangiotensynogenciążastan przedrzucawkowy
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