Tom 8, Nr 3-4 (2023)
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Opublikowany online: 2024-03-15
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Eksport do Mediów Społecznościowych

Eksport do Mediów Społecznościowych

Odmienności funkcjonowania układu renina–angiotensyna–aldosteron w ciąży

Paweł Pietruski1, Katarzyna Kosińska-Kaczyńska1
Ginekologia i Perinatologia Praktyczna 2023;8(3-4):156-162.

Streszczenie

Układ renina–angiotensyna–aldosteron (RAAS) jest jednym z najważniejszych systemów utrzymujących ciśnienie krwi i równowagę wodno-elektrolitową. Szereg zachodzących w nim w trakcie ciąży zmian pozwala na prawidłową implantację, rozwój łożyska oraz utrzymanie przepływu maciczno-łożyskowego. Większość elementów układu wykazuje w ciąży zwiększoną ekspresję, układ krwionośny pozostaje jednak oporny na działanie wazokonstrykcyjne RAAS. Dysregulacja RAAS oraz obecność przeciwciał przeciwko receptorom angiotensyny typu 1 odgrywają istotną rolę w patogenezie stanu przedrzucawkowego, indukując nadwrażliwość na angiotensynę II.

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