Tom 8, Nr 2 (2023)
Artykuł przeglądowy
Opublikowany online: 2023-10-05
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Współczesne leczenie endometriozy — jaką rolę odgrywają gestageny?
Ginekologia i Perinatologia Praktyczna 2023;8(2):64-73.
Streszczenie
Endometrioza jest chorobą powszechną, dotykającą około 6–10% kobiet w wieku reprodukcyjnym. Wiąże się
przede wszystkim z bolesnymi miesiączkami, dyspareunią, przewlekłym bólem miednicy mniejszej oraz niepłodnością.
Poza metodami operacyjnymi kluczową rolę odgrywa leczenie farmakologiczne w formie terapii empirycznej
lub uzupełniającej do leczenia chirurgicznego. W tym zakresie dostępnych jest kilka grup leków. Ze względu
na skuteczność, profil bezpieczeństwa i stosunkowo niewielką ilość skutków ubocznych czołowe miejsce wśród
nich zajmują progestageny, czyli syntetyczne pochodne progesteronu. Stosowane są w monoterapii, w doustnej
antykoncepcji dwuskładnikowej, w iniekcjach domięśniowych oraz systemie wewnątrzmacicznym. Niniejszy artykuł
stanowi przegląd podstawowych leków z grupy progestagenów połączony z opisem ich podstawowego działania.
Słowa kluczowe: endometriozaprogestagenybolesne miesiączkowanie
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