Tom 15, Nr 1 (2023)
Opis przypadku
Opublikowany online: 2024-05-28
Wyświetlenia strony
351
Wyświetlenia/pobrania artykułu
17
Zapalenie jelita grubego po immunoterapii
DOI: 10.5603/gek.99710
Gastroenterologia Kliniczna 2023;15(1):44-49.
Streszczenie
Zastosowanie inhibitorów punktu kontrolnego (ICIs, immune checkpoint inhibitors) w terapii onkologicznej zmieniło strategię leczenia nowotworów w zaawansowanym stadium choroby. Leczenie to wiąże się jednak z występowaniem działań niepożądanych, przy czym do najczęstszych w immunoterapii należy biegunka, która wymaga przerwania leczenia onkologicznego. W różnicowaniu przyczyny biegunki oprócz infekcji należy wziąć pod uwagę zapalenie jelit o podłożu autoimmunologicznym (IR-colitis, immune related colits) oraz zaostrzenie nieswoistej choroby zapalnej jelit. Celem poniższej publikacji jest przedstawienie zasad diagnostyki oraz leczenia biegunki związanej ze stosowaniem inhibitorów punktu kontrolnego na podstawie przypadków klinicznych pacjentów onkologicznychotrzymujących immunoterapię.
Słowa kluczowe: immunoterapiainhibitory punktu kontrolnegobiegunkazapalenie jelit po immunoterapiiwrzodziejące zapalenie jelita grubegochoroba Leśniowskiego-Crohna
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