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Tom 15, Nr 1 (2021)
Inne materiały uzgodnione z Redakcją
Opublikowany online: 2021-02-15

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Eksport do Mediów Społecznościowych

Eksport do Mediów Społecznościowych

Probiotykoterapia w zespole metabolicznym

Małgorzata Moszak1, Paweł Bogdański1
Forum Medycyny Rodzinnej 2021;15(1):14-33.

Streszczenie

Mikrobiota jelitowa (GM) pełni w organizmie liczne funkcje warunkujące homeostazę metaboliczną — między innymi uczestniczy w syntezie witamin K, B1 , B6, B12 oraz kwasu foliowego, trawieniu i wchłanianiu składników odżywczych, przemianach cholesterolu i kwasów żółciowych oraz stymulacji układu odpornościowego. Ostatnie dwudziestolecie jest okresem intensywnych badań nad florą bakteryjną oraz zależnościami między jej ilościowymi i jakościowymi zabur zeniami a chorobami metabolicznymi, takimi jak otyłość, cukr zyca typu 2, osteoporoza, hipercholesterolemia oraz stłuszczenie wątroby. Wśród mechanizmów łączących zaburzenia składu i aktywności GM z rozwojem chorób metabolicznych wymienia deregulację przemian energetycznych, utratę integralności błony śluzowej jelit prowadzącą do endotoksemii i stanu zapalnego, zmianę metabolizmu kwasów żółciowych i sygnalizacji receptora farnezoidowego X oraz wpływ metabolitów bakteryjnych (SCFA, TMAO, LPS) na regulacjękluczowych szlaków metabolicznych. Pozytywny wpływ probiotyków na przebieg leczenia otyłości i zabur zeń metabolicznych związanych z nadmierną masą ciała wynika z ich zdolności kształtowania ekosystemu bakterii jelitowych. Zaprezentowane w opracowaniu dane pochodzące z licznych metaanaliz oraz badań klinicznych dostarczają dowodów na istotny potencjał probiotyków w poprawie wykładników gospoda rki węglowodanowej, lipidowej oraz ciśnienia tętniczego, a także prawdopodobny wpływ na redukcję masy ciała i zmianę jego składu. Naukowcy podkreślają jednak, że racjonalizacja użycia drobnoustrojów probiotycznych w leczeniu zespołu metabolicznego wymaga zastosowania probiotykoterapii o przemyślanej specyfice szczepów bakterii lub/i ich połączeń, dawce, czasie trwania i formie. Określenie tych elementów wydaje się kluczowym zadaniem przyszłych badań.

Słowa kluczowe: probiotykimikrobiota jelitowazespół metabolicznynadwagaotyłośćcukrzycahiperlipidemianadciśnienie tętnicze

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Referencje

  1. Day C. Metabolic syndrome, or What you will: definitions and epidemiology. Diab Vasc Dis Res. 2007; 4(1): 32–38.
    CrossRefPubMed
  2. Alberti KG, Eckel RH, Grundy SM, et al. International Diabetes Federation Task Force on Epidemiology and Prevention, Hational Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16): 1640–1645.
    CrossRefPubMed
  3. Manrique P, Bolduc B, Walk ST, et al. Healthy human gut phageome. Proc Natl Acad Sci U S A. 2016; 113(37): 10400–10405.
    CrossRefPubMed
  4. Rinninella E, Raoul P, Cintoni M, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019; 7(1).
    CrossRefPubMed
  5. Turnbaugh PJ, Ley RE, Hamady M, et al. The human microbiome project. Nature. 2007; 449(7164): 804–810.
    CrossRefPubMed
  6. Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health. Gastroenterology. 2014; 146(6): 1449–1458.
    CrossRefPubMed
  7. Oliphant K, Allen-Vercoe E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome. 2019; 7(1): 91.
    CrossRefPubMed
  8. Dieterich W, Schink M, Zopf Y. Microbiota in the Gastrointestinal Tract. Med Sci (Basel). 2018; 6(4).
    CrossRefPubMed
  9. Sommer F, Bäckhed F. The gut microbiota--masters of host development and physiology. Nat Rev Microbiol. 2013; 11(4): 227–238.
    CrossRefPubMed
  10. Baumann-Dudenhoeffer AM, D'Souza AW, Tarr PI, et al. Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes. Nat Med. 2018; 24(12): 1822–1829.
    CrossRefPubMed
  11. Isolauri E, Rautava S, Salminen S, et al. Early-Life Nutrition and Microbiome Development. Nestle Nutr Inst Workshop Ser. 2019; 90: 151–162.
    CrossRefPubMed
  12. Cong X, Judge M, Xu W, et al. Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants. Nurs Res. 2017; 66(2): 123–133.
    CrossRefPubMed
  13. Castaner O, Goday A, Park YM, et al. The Gut Microbiome Profile in Obesity: A Systematic Review. Int J Endocrinol. 2018; 2018: 4095789.
    CrossRefPubMed
  14. Moszak M, Szulińska M, Bogdański P. You Are What You Eat-The Relationship between Diet, Microbiota, and Metabolic Disorders-A Review. Nutrients. 2020; 12(4).
    CrossRefPubMed
  15. Yan J, Liu L, Zhu Y, et al. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health. 2014; 14: 1267.
    CrossRefPubMed
  16. Valles-Colomer M, Falony G, Darzi Y, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol. 2019; 4(4): 623–632.
    CrossRefPubMed
  17. Sekirov I, Russell SL, Antunes LC, et al. Gut microbiota in health and disease. Physiol Rev. 2010; 90(3): 859–904.
    CrossRefPubMed
  18. Dominguez-Bello MG, Blaser MJ, Ley RE, et al. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011; 140(6): 1713–1719.
    CrossRefPubMed
  19. Nawrocka M, Szulińska M, Bogdański P. Rola mikroflory jelitowej w patogenezie i leczeniu otyłości oraz zespołu metabolicznego. Forum Zaburzeń Metab. 2015; 6(3): 95–102.
  20. Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (8.11.2020).
  21. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122): 1027–1031.
    CrossRefPubMed
  22. Bäckhed F, Manchester JK, Semenkovich CF, et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007; 104(3): 979–984.
    CrossRefPubMed
  23. Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell. 2006; 124(4): 837–848.
    CrossRefPubMed
  24. Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013; 498(7452): 99–103.
    CrossRefPubMed
  25. Larsen N, Vogensen FK, van den Berg FWJ, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 2010; 5(2): e9085.
    CrossRefPubMed
  26. A metagenome-wide association study of gut microbiota in type 2 diabetes. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/23023125?dopt=Abstract (28.01.2020).
  27. Wang X, Xu X, Xia Y. Further analysis reveals new gut microbiome markers of type 2 diabetes mellitus. Antonie Van Leeuwenhoek. 2017; 110(3): 445–453.
    CrossRefPubMed
  28. Tilg H, Moschen AR. Microbiota and diabetes: an evolving relationship. Gut. 2014; 63(9): 1513–1521.
    CrossRefPubMed
  29. Saito T, Hayashida H, Furugen R, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007; 56(7): 1761–1772.
    CrossRefPubMed
  30. Creely SJ, McTernan PG, Kusminski CM, et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab. 2007; 292(3): E740–E747.
    CrossRefPubMed
  31. Jellinger PS, Handelsman Y, Rosenblit PD, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease ― executive summary. Endocr Pract. 2017; 23(4): 479–497.
    CrossRefPubMed
  32. Caesar R, Tremaroli V, Kovatcheva-Datchary P, et al. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling. Cell Metab. 2015; 22(4): 658–668.
    CrossRefPubMed
  33. Le Roy T, Lécuyer E, Chassaing B, et al. The intestinal microbiota regulates host cholesterol homeostasis. BMC Biol. 2019; 17(1): 94.
    CrossRefPubMed
  34. Cotillard A, Kennedy SP, Kong LC, et al. ANR MicroObes consortium. Dietary intervention impact on gut microbial gene richness. Nature. 2013; 500(7464): 585–588.
    CrossRefPubMed
  35. Le Chatelier E, Nielsen T, Qin J, et al. MetaHIT consortium. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013; 500(7464): 541–546.
    CrossRefPubMed
  36. Jose PA, Raj D. Gut microbiota in hypertension. Curr Opin Nephrol Hypertens. 2015; 24(5): 403–409.
    CrossRefPubMed
  37. Silveira-Nunes G, Durso DF, Jr. LRA de O, Cunha EHM, Maioli TU, Vieira AT, i in. Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population. Front Pharmacol . https://www.frontiersin.org/articles/10.3389/fphar.2020.00258/full (8.11.2020).
  38. Verhaar BJH, Prodan A, Nieuwdorp M, et al. Gut Microbiota in Hypertension and Atherosclerosis: A Review. Nutrients. 2020; 12(10).
    CrossRefPubMed
  39. Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes. 2009; 58(7): 1509–1517.
    CrossRefPubMed
  40. Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science. 2012; 336(6086): 1262–1267.
    CrossRefPubMed
  41. Goffredo M, Mass K, Parks EJ, et al. Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth. J Clin Endocrinol Metab. 2016; 101(11): 4367–4376.
    CrossRefPubMed
  42. Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther. 2011; 130(2): 202–212.
    CrossRefPubMed
  43. Gentile CL, Weir TL. The gut microbiota at the intersection of diet and human health. Science. 2018; 362(6416): 776–780.
    CrossRefPubMed
  44. Sonnenburg E, Smits S, Tikhonov M, et al. Diet-induced extinctions in the gut microbiota compound over generations. Nature. 2016; 529(7585): 212–215.
    CrossRef
  45. Samuel BS, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A. 2008; 105(43): 16767–16772.
    CrossRefPubMed
  46. Cani PD, Osto M, Geurts L, et al. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 2012; 3(4): 279–288.
    CrossRefPubMed
  47. Rheinheimer J, de Souza BM, Cardoso NS, et al. Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review. Metabolism. 2017; 74: 1–9.
    CrossRefPubMed
  48. Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44): 15718–15723.
    CrossRefPubMed
  49. Schugar RC, Shih DM, Warrier M, et al. The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue. Cell Rep. 2017; 20(1): 2451–2461.
    CrossRefPubMed
  50. Wahlström A, Sayin SI, Marschall HU, et al. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metab. 2016; 24(1): 41–50.
    CrossRefPubMed
  51. Zhang Y, Lee FY, Barrera G, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A. 2006; 103(4): 1006–1011.
    CrossRefPubMed
  52. Duran-Sandoval D, Mautino G, Martin G, et al. Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes. 2004; 53(4): 890–898.
    CrossRefPubMed
  53. Iizuka K, Miller B, Uyeda K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab. 2006; 291(2): E358–E364.
    CrossRefPubMed
  54. Probiotics in food: health and nutritional properties and guidelines for evaluation. NLM Catalog. NCBI. https://www.ncbi.nlm.nih.gov/nlmcatalog/101617803 (5.11.2020).
  55. Mojka K. Probiotics, prebiotics and synbiotics ― characteristics and functions. Probl Hig Epidemiol. 2014; 95(3): 541–549.
  56. Sáez-Lara MJ, Robles-Sanchez C, Ruiz-Ojeda FJ, et al. Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci. 2016; 17(6).
    CrossRefPubMed
  57. Koutnikova H, Genser B, Monteiro-Sepulveda M, et al. Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2019; 9(3): e017995.
    CrossRefPubMed
  58. Dong Y, Xu M, Chen L, et al. Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials. Ann Nutr Metab. 2019; 74(3): 224–241.
    CrossRefPubMed
  59. Tenorio-Jiménez C, Martínez-Ramírez MJ, Gil Á, et al. Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials. Nutrients. 2020; 12(1).
    CrossRefPubMed
  60. Skonieczna-Żydecka K, Kaźmierczak-Siedlecka K, Kaczmarczyk M, et al. The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People-A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials. J Clin Med. 2020; 9(6).
    CrossRefPubMed
  61. Kassaian N, Feizi A, Aminorroaya A, et al. Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: A randomized controlled trial. Diabetes Metab Syndr. 2019; 13(5): 2991–2996.
    CrossRefPubMed
  62. Mohammadi-Sartang M, Bellissimo N, Totosy de Zepetnek JO, et al. The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial. Nutr Metab Cardiovasc Dis. 2018; 28(6): 565–574.
    CrossRefPubMed
  63. Szulińska M, Łoniewski I, van Hemert S, et al. Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial. Nutrients. 2018; 10(6).
    CrossRefPubMed
  64. Szulińska M, Łoniewski I, Skrypnik K, et al. Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women-A 12-Week Placebo-Controlled and Randomized Clinical Study. Nutrients. 2018; 10(11).
    CrossRefPubMed
  65. Barreto FM, Colado Simão AN, Morimoto HK, et al. Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome. Nutrition. 2014; 30(7-8): 939–942.
    CrossRefPubMed
  66. Tenorio-Jiménez C, Martínez-Ramírez MJ, Del Castillo-Codes I, et al. V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study. Nutrients. 2019; 11(8).
    CrossRefPubMed
  67. Bernini LJ, Simão AN, Alfieri DF, et al. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome. Nutrition. 2016; 32(6): 716–719.
    CrossRefPubMed
  68. Rezazadeh L, Gargari BP, Jafarabadi MA, et al. Effects of probiotic yogurt on glycemic indexes and endothelial dysfunction markers in patients with metabolic syndrome. Nutrition. 2019; 62: 162–168.
    CrossRefPubMed
  69. Tripolt NJ, Leber B, Blattl D, et al. Short communication: Effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity, β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome--a pilot study. J Dairy Sci. 2013; 96(1): 89–95.
    CrossRefPubMed
  70. Stadlbauer V, Leber B, Lemesch S, et al. Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study. PLoS One. 2015; 10(10): e0141399.
    CrossRefPubMed
  71. Borgeraas H, Johnson LK, Skattebu J, et al. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2018; 19(2): 219–232.
    CrossRefPubMed
  72. Crovesy L, Ostrowski M, Ferreira DM, et al. Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes (Lond). 2017; 41(11): 1607–1614.
    CrossRefPubMed
  73. Wang ZB, Xin SS, Ding LN, et al. The potential role of probiotics in controlling overweight/obesity and associated metabolic parameters in adults: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019; 2019: 3862971.
    CrossRefPubMed
  74. Suzumura EA, Bersch-Ferreira ÂC, Torreglosa CR, et al. Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: a systematic review and meta-analyses of randomized trials. Nutr Rev. 2019; 77(6): 430–450.
    CrossRefPubMed
  75. López-Moreno A, Suárez A, Avanzi C, et al. Probiotic strains and intervention total doses for modulating obesity-related microbiota dysbiosis: a systematic review and meta-analysis. Nutrients. 2020; 12(7).
    CrossRefPubMed
  76. John GK, Wang L, Nanavati J, et al. Dietary alteration of the gut microbiome and its impact on weight and fat mass: a systematic review and meta-analysis. Genes (Basel). 2018; 9(3).
    CrossRefPubMed
  77. Pedret A, Valls RM, Calderón-Pérez L, et al. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2019; 43(9): 1863–1868.
    CrossRefPubMed
  78. Zarrati M, Raji Lahiji M, Salehi E, et al. Effects of probiotic yogurt on serum omentin-1, adropin, and nesfatin-1 concentrations in overweight and obese participants under low-calorie diet. Probiotics Antimicrob Proteins. 2019; 11(4): 1202–1209.
    CrossRefPubMed
  79. Gomes AC, de Sousa RG, Botelho PB, et al. The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double-blind, randomized trial. Obesity (Silver Spring). 2017; 25(1): 30–38.
    CrossRefPubMed
  80. Kim J, Yun JM, Kim MiK, et al. Lactobacillus gasseri BNR17 supplementation reduces the visceral fat accumulation and waist circumference in obese adults: a randomized, double-blind, placebo-controlled trial. J Med Food. 2018; 21(5): 454–461.
    CrossRefPubMed
  81. Sudha MR, Ahire JJ, Jayanthi N, et al. Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study. Benef Microbes. 2019; 10(8): 855–866.
    CrossRefPubMed
  82. Karbaschian Z, Mokhtari Z, Pazouki A, et al. Probiotic supplementation in morbid obese patients undergoing one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB) surgery: a randomized, double-blind, placebo-controlled, clinical trial. Obes Surg. 2018; 28(9): 2874–2885.
    CrossRefPubMed
  83. Gurung M, Li Z, You H, et al. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020; 51: 102590.
    CrossRefPubMed
  84. Zhang Q, Wu Y, Fei X. Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Medicina (Kaunas). 2016; 52(1): 28–34.
    CrossRefPubMed
  85. Rittiphairoj T, Pongpirul K, Janchot K, et al. Probiotics contribute to glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Adv Nutr. 2020 [Epub ahead of print].
    CrossRefPubMed
  86. Ardeshirlarijani E, Tabatabaei-Malazy O, Mohseni S, et al. Effect of probiotics supplementation on glucose and oxidative stress in type 2 diabetes mellitus: a meta-analysis of randomized trials. Daru. 2019; 27(2): 827–837.
    CrossRefPubMed
  87. Yao K, Zeng L, He Q, et al. Effect of probiotics on glucose and lipid metabolism in type 2 diabetes mellitus: a meta-analysis of 12 randomized controlled trials. Med Sci Monit. 2017; 23: 3044–3053.
    CrossRefPubMed
  88. Samah S, Ramasamy K, Lim SM, et al. Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2016; 118: 172–182.
    CrossRefPubMed
  89. Sun J, Buys NJ. Glucose- and glycaemic factor-lowering effects of probiotics on diabetes: a meta-analysis of randomised placebo-controlled trials. Br J Nutr. 2016; 115(7): 1167–1177.
    CrossRefPubMed
  90. Hu YM, Zhou F, Yuan Y, et al. Effects of probiotics supplement in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. Med Clin (Barc). 2017; 148(8): 362–370.
    CrossRefPubMed
  91. Kasińska MA, Drzewoski J. Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Pol Arch Med Wewn. 2015; 125(11): 803–813.
    CrossRefPubMed
  92. Wang X, Juan QF, He YW, et al. Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials. J Pediatr Endocrinol Metab. 2017; 30(6): 611–622.
    CrossRefPubMed
  93. Hendijani F, Akbari V. Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clin Nutr. 2018; 37(2): 532–541.
    CrossRefPubMed
  94. Jafar-Abadi MA, Dehghani A, Khalili L, et al. A meta-analysis of randomized controlled trials of the effect of probiotic food or supplement on glycemic response and body mass index in patients with type 2 diabetes, updating the evidence. Curr Diabetes Rev. 2020 [Epub ahead of print].
    CrossRefPubMed
  95. Firouzi S, Majid HA, Ismail A, et al. Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial. Eur J Nutr. 2017; 56(4): 1535–1550.
    CrossRefPubMed
  96. Kobyliak N, Falalyeyeva T, Mykhalchyshyn G, et al. Effect of alive probiotic on insulin resistance in type 2 diabetes patients: Randomized clinical trial. Diabetes Metab Syndr. 2018; 12(5): 617–624.
    CrossRefPubMed
  97. Tonucci LB, Olbrich Dos Santos KM, Licursi de Oliveira L, et al. Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. Clin Nutr. 2017; 36(1): 85–92.
    CrossRefPubMed
  98. Hsieh MC, Tsai WH, Jheng YP, et al. The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial. Sci Rep. 2018; 8(1): 16791.
    CrossRefPubMed
  99. Madempudi RS, Ahire JJ, Neelamraju J, et al. Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study. PLoS One. 2019; 14(11): e0225168.
    CrossRefPubMed
  100. Razmpoosh E, Javadi A, Ejtahed HS, et al. The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: A randomized placebo controlled trial. Diabetes Metab Syndr. 2019; 13(1): 175–182.
    CrossRefPubMed
  101. Sabico S, Al-Mashharawi A, Al-Daghri NM, et al. Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019; 38(4): 1561–1569.
    CrossRefPubMed
  102. Tajabadi-Ebrahimi M, Sharifi N, Farrokhian A, et al. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Exp Clin Endocrinol Diabetes. 2017; 125(1): 21–27.
    CrossRefPubMed
  103. Dixon A, Robertson K, Yung A, et al. Efficacy of probiotics in patients of cardiovascular disease risk: a systematic review and meta-analysis. Curr Hypertens Rep. 2020; 22(9): 74.
    CrossRefPubMed
  104. Ejtahed HS, Ardeshirlarijani E, Tabatabaei-Malazy O, et al. Effect of probiotic foods and supplements on blood pressure: a systematic review of meta-analyses studies of controlled trials. J Diabetes Metab Disord. 2020; 19(1): 617–623.
    CrossRefPubMed
  105. Chi C, Li C, Wu D, et al. Effects of probiotics on patients with hypertension: a systematic review and meta-analysis. Curr Hypertens Rep. 2020; 22(5): 34.
    CrossRefPubMed
  106. He J, Zhang F, Han Y. Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: A meta-analysis of RCTs. Medicine (Baltimore). 2017; 96(51): e9166.
    CrossRefPubMed
  107. Ito M, Kusuhara S, Yokoi W, et al. Streptococcus thermophilus fermented milk reduces serum MDA-LDL and blood pressure in healthy and mildly hypercholesterolaemic adults. Benef Microbes. 2017; 8(2): 171–178.
    CrossRefPubMed
  108. Mo R, Zhang X, Yang Y. Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials. Med Clin (Barc). 2019; 152(12): 473–481.
    CrossRefPubMed
  109. Pourrajab B, Fatahi S, Dehnad A, et al. The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2020; 30(1): 11–22.
    CrossRefPubMed
  110. Yan S, Tian Z, Li M, et al. Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis. Food Funct. 2019; 10(3): 1747–1759.
    CrossRefPubMed
  111. Gadelha CJ, Bezerra AN. Effects of probiotics on the lipid profile: systematic review. J Vasc Bras. 2019; 18: e20180124.
    CrossRefPubMed
  112. Wu Y, Zhang Q, Ren Y, et al. Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. PLoS One. 2017; 12(6): e0178868.
    CrossRefPubMed
  113. Schoeler M, Caesar R. Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord. 2019; 20(4): 461–472.
    CrossRefPubMed
  114. An HMi, Park SY, Lee DoK, et al. Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats. Lipids Health Dis. 2011; 10: 116.
    CrossRefPubMed
  115. Zheng HJ, Guo J, Jia Qi, et al. The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019; 142: 303–313.
    CrossRefPubMed
  116. Tabrizi R, Ostadmohammadi V, Lankarani KB, et al. The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. Eur J Pharmacol. 2019; 852: 254–264.
    CrossRefPubMed

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