Tom 14, Nr 1 (2020)
Wybrane problemy kliniczne
Opublikowany online: 2020-03-01
Pobierz cytowanie

Is there an association between hereditary hemochromatosis and colon cancer in children?

Teresa Stachowicz-Stencel, Anna Synakiewicz
Forum Medycyny Rodzinnej 2020;14(1):40-44.

dostęp płatny

Tom 14, Nr 1 (2020)
Wybrane problemy kliniczne
Opublikowany online: 2020-03-01

Streszczenie

Colon cancer is very rare in children and adolescents, so it remains in an advanced stage at diagnosis. Hereditary hemochromatosis (HH) is an autosomal recessive disease in which iron overload leads to dysfunction of several organs. Elevated body iron stores has association between HFE genotype and risk for some types of cancer. There are HFE gene mutations, including the C282Y and the H63D mutation in the majority of individuals with phenotypic hemochromatosis. The HFE gene mutations may predispose to an increasing risk of colon cancer. Careful clinical and colonoscopic evaluation in patients with these mutations may lead to detect cancer at an earlier stage. We report a case of adenocarcinoma of the colon in 17-year old male with HH and risk of gastrointestinal cancer in patients with hemochromatosis gene mutations.

Streszczenie

Colon cancer is very rare in children and adolescents, so it remains in an advanced stage at diagnosis. Hereditary hemochromatosis (HH) is an autosomal recessive disease in which iron overload leads to dysfunction of several organs. Elevated body iron stores has association between HFE genotype and risk for some types of cancer. There are HFE gene mutations, including the C282Y and the H63D mutation in the majority of individuals with phenotypic hemochromatosis. The HFE gene mutations may predispose to an increasing risk of colon cancer. Careful clinical and colonoscopic evaluation in patients with these mutations may lead to detect cancer at an earlier stage. We report a case of adenocarcinoma of the colon in 17-year old male with HH and risk of gastrointestinal cancer in patients with hemochromatosis gene mutations.

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Słowa kluczowe

hemochromatosis, colon cancer, treatment, children

Informacje o artykule
Tytuł

Is there an association between hereditary hemochromatosis and colon cancer in children?

Czasopismo

Forum Medycyny Rodzinnej

Numer

Tom 14, Nr 1 (2020)

Strony

40-44

Data publikacji on-line

2020-03-01

Rekord bibliograficzny

Forum Medycyny Rodzinnej 2020;14(1):40-44.

Słowa kluczowe

hemochromatosis
colon cancer
treatment
children

Autorzy

Teresa Stachowicz-Stencel
Anna Synakiewicz

Referencje (26)
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