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Effect of Dermedic Normacne Ultra-moisturizing cream supporting pharmacotherapy on selected barrier parameters epidermal and skin hydration in acne vulgaris: single-center, double-blind, controlled study
Affiliations- Dermoklinika Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
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Abstract
Introduction: Acne vulgaris is a common skin disease that mainly affects young people. Acne skin is characterized by excess sebum secretion, which leads to clogged hair follicles, and is a substrate for the formation of blackheads and papular eruptions. One of the basic methods of fighting acne is the use of retinoids, which can irritate and dry the skin. Therefore, it is necessary to conduct research on innovative preparations, which, thanks to their formula, will constitute a therapy supporting anti-acne treatment. The aim of the study was to examine the clinical condition of the skin of patients during treatment with retinoids due to acne and to evaluate its biophysical parameters before and 4 weeks after daily use of Dermedic Normacne Ultra-moisturizing and to compare them with the results obtained by patients using the preparation without active substances.
Material and methods: We enrolled 40 patients with acne vulgaris of the facial skin on treatment with oral or topical retinoids in a double-blind study. Patients were randomly assigned to one of two groups. Half of the participants in the study received the Dermedic Normacne Ultra-moisturizing preparation for 4 weeks, while another 20 participants used the preparation without active substances. In each patient, the biophysical parameters of the skin: pH, TEWL and sebum content were assessed in 2 locations: on the forehead and left cheek before entering the study and after 4 weeks of using the preparation.
Results: In the experimental group, after 4 weeks of treatment, a statistically significant reduction in the level of TEWL was observed both on the cheek (12.44 } 0.65 g/h/m2 vs. 9.88 } 0.80g/h/ m2) and on the skin of the forehead (12.53 } 0.66 g/h/m2 vs. 11.15 } 0.91 g/h/m2). In the control group, the TEWL level did not change significantly. In addition, subjective improvement in skin properties was observed, without significantly affecting the skin’s pH value and sebum level.
Conclusions: The results of the study show clinical improvement of acne skin after the application of Dermedic Normacne Ultra-moisturizing cream supporting pharmacotherapy.
Abstract
Introduction: Acne vulgaris is a common skin disease that mainly affects young people. Acne skin is characterized by excess sebum secretion, which leads to clogged hair follicles, and is a substrate for the formation of blackheads and papular eruptions. One of the basic methods of fighting acne is the use of retinoids, which can irritate and dry the skin. Therefore, it is necessary to conduct research on innovative preparations, which, thanks to their formula, will constitute a therapy supporting anti-acne treatment. The aim of the study was to examine the clinical condition of the skin of patients during treatment with retinoids due to acne and to evaluate its biophysical parameters before and 4 weeks after daily use of Dermedic Normacne Ultra-moisturizing and to compare them with the results obtained by patients using the preparation without active substances.
Material and methods: We enrolled 40 patients with acne vulgaris of the facial skin on treatment with oral or topical retinoids in a double-blind study. Patients were randomly assigned to one of two groups. Half of the participants in the study received the Dermedic Normacne Ultra-moisturizing preparation for 4 weeks, while another 20 participants used the preparation without active substances. In each patient, the biophysical parameters of the skin: pH, TEWL and sebum content were assessed in 2 locations: on the forehead and left cheek before entering the study and after 4 weeks of using the preparation.
Results: In the experimental group, after 4 weeks of treatment, a statistically significant reduction in the level of TEWL was observed both on the cheek (12.44 } 0.65 g/h/m2 vs. 9.88 } 0.80g/h/ m2) and on the skin of the forehead (12.53 } 0.66 g/h/m2 vs. 11.15 } 0.91 g/h/m2). In the control group, the TEWL level did not change significantly. In addition, subjective improvement in skin properties was observed, without significantly affecting the skin’s pH value and sebum level.
Conclusions: The results of the study show clinical improvement of acne skin after the application of Dermedic Normacne Ultra-moisturizing cream supporting pharmacotherapy.
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Keywords
acne vulgaris; cream
About this articleTitle
Effect of Dermedic Normacne Ultra-moisturizing cream supporting pharmacotherapy on selected barrier parameters epidermal and skin hydration in acne vulgaris: single-center, double-blind, controlled study
Journal
Issue
Article type
Research paper
Pages
37-42
Published online
2021-06-30
Page views
464
Article views/downloads
40
DOI
Bibliographic record
Forum Dermatologicum 2021;7(2):37-42.
Keywords
acne vulgaris
cream
Authors
Aleksandra Lesiak
Joanna Narbutt
Magdalena Ciążyńska
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