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Vol 3, No 1 (2017)
Research paper
Published online: 2017-02-22
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Role of MMP-8 in photoaging and photocarcinogenesis

Magdalena Anna Ciążyńska, Joanna Narbutt, Anna Woźniacka, Aleksandra Lesiak
Forum Dermatologicum 2017;3(1):3-7.

open access

Vol 3, No 1 (2017)
ORIGINAL ARTICLES
Published online: 2017-02-22

Abstract

Introduction: Ultraviolet radiation (UVR) is especially harmful to human skin. It mostly contributes to skin photoaging that is associated with skin carcinomas, such as the most common skin cancer — basal cell carcinoma (BCC). It has been shown that significant role in skin carcinogenesis plays short-wavelength UVB radiation. What is more, UVR by changing the expression of matrix metalloproteinases (MMPs) in skin contributes to photoaging and plays an important role in photocarcinogenesis. MMP-8 is one of collagenases that is released during inflammatory process.
Material and methods: The study group consists of 85 individuals (22 patients with diagnosed BCC and 63 healthy volunteers that have been exposed to various doses of UVB radiation) in order to evaluate the expression of MMP-8 protein in skin biopsies. The Western-blot method was used to analyse the results.
Results: The expression of MMP-8 has been observed in all skin biopsies. The performed analysis did not present statistical significant difference in expression of MMP-8 between skin samples with BCC or exposed to UVR in comparison to healthy skin samples.
Conclusions: The role of MMP-8 in skin photoaging has little activity in skin following UVB radiation and it is slightly
probable that MMP-8 contributes to photoaging and photocancerogenesis.

Abstract

Introduction: Ultraviolet radiation (UVR) is especially harmful to human skin. It mostly contributes to skin photoaging that is associated with skin carcinomas, such as the most common skin cancer — basal cell carcinoma (BCC). It has been shown that significant role in skin carcinogenesis plays short-wavelength UVB radiation. What is more, UVR by changing the expression of matrix metalloproteinases (MMPs) in skin contributes to photoaging and plays an important role in photocarcinogenesis. MMP-8 is one of collagenases that is released during inflammatory process.
Material and methods: The study group consists of 85 individuals (22 patients with diagnosed BCC and 63 healthy volunteers that have been exposed to various doses of UVB radiation) in order to evaluate the expression of MMP-8 protein in skin biopsies. The Western-blot method was used to analyse the results.
Results: The expression of MMP-8 has been observed in all skin biopsies. The performed analysis did not present statistical significant difference in expression of MMP-8 between skin samples with BCC or exposed to UVR in comparison to healthy skin samples.
Conclusions: The role of MMP-8 in skin photoaging has little activity in skin following UVB radiation and it is slightly
probable that MMP-8 contributes to photoaging and photocancerogenesis.

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Keywords

ultra violet radiation; photocancerogenesis; matrix metalloproteinases-8

About this article
Title

Role of MMP-8 in photoaging and photocarcinogenesis

Journal

Forum Dermatologicum

Issue

Vol 3, No 1 (2017)

Article type

Research paper

Pages

3-7

Published online

2017-02-22

Page views

720

Article views/downloads

685

Bibliographic record

Forum Dermatologicum 2017;3(1):3-7.

Keywords

ultra violet radiation
photocancerogenesis
matrix metalloproteinases-8

Authors

Magdalena Anna Ciążyńska
Joanna Narbutt
Anna Woźniacka
Aleksandra Lesiak

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