Role of MMP-8 in photoaging and photocarcinogenesis
Abstract
Introduction: Ultraviolet radiation (UVR) is especially harmful to human skin. It mostly contributes to skin photoaging that is associated with skin carcinomas, such as the most common skin cancer — basal cell carcinoma (BCC). It has been shown that significant role in skin carcinogenesis plays short-wavelength UVB radiation. What is more, UVR by changing the expression of matrix metalloproteinases (MMPs) in skin contributes to photoaging and plays an important role in photocarcinogenesis. MMP-8 is one of collagenases that is released during inflammatory process.
Material and methods: The study group consists of 85 individuals (22 patients with diagnosed BCC and 63 healthy volunteers that have been exposed to various doses of UVB radiation) in order to evaluate the expression of MMP-8 protein in skin biopsies. The Western-blot method was used to analyse the results.
Results: The expression of MMP-8 has been observed in all skin biopsies. The performed analysis did not present statistical significant difference in expression of MMP-8 between skin samples with BCC or exposed to UVR in comparison to healthy skin samples.
Conclusions: The role of MMP-8 in skin photoaging has little activity in skin following UVB radiation and it is slightly
probable that MMP-8 contributes to photoaging and photocancerogenesis.
Keywords: ultra violet radiationphotocancerogenesismatrix metalloproteinases-8
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