open access
Interdisciplinary aspect of Werner syndrome — a case study
open access
Abstract
The paper presents a case of 40-year-old patient with a history on the Werner syndrome who was admitted to the
Department of Dermatology due to recurrent eczema on lower legs and feet. The patient’s medical history revealed
numerous internal diseases, hoarseness and premature hair loss. Physical examination showed visible erythema and
trophic changes on the skin of the lower legs. There were also other skin manifestations typical for the premature
aging syndrome — a generalized atrophy of the skin, subcutaneous tissue atrophy, muscle contractures in the
elbows and hips and bird-like facial appearance. The treatment applied resulted in partial clinical improvement.
Abstract
The paper presents a case of 40-year-old patient with a history on the Werner syndrome who was admitted to the
Department of Dermatology due to recurrent eczema on lower legs and feet. The patient’s medical history revealed
numerous internal diseases, hoarseness and premature hair loss. Physical examination showed visible erythema and
trophic changes on the skin of the lower legs. There were also other skin manifestations typical for the premature
aging syndrome — a generalized atrophy of the skin, subcutaneous tissue atrophy, muscle contractures in the
elbows and hips and bird-like facial appearance. The treatment applied resulted in partial clinical improvement.
Keywords
progeria; premature aging; lower leg eczema
Title
Interdisciplinary aspect of Werner syndrome — a case study
Journal
Issue
Article type
Case report
Pages
12-15
Published online
2017-02-22
Page views
455
Article views/downloads
4318
Bibliographic record
Forum Dermatologicum 2017;3(1):12-15.
Keywords
progeria
premature aging
lower leg eczema
Authors
Magdalena Świstak
Julia Nowowiejska
Anna Baran
Iwona Flisiak
- Reich A, Heisig M, Baran E. Zespół Wernera - zespół przedwczesnego starzenia imitujący twardzinę ograniczoną. Post Dermatol Alergol 2010; 27. ; 6: 490–494.
- Nedoszytko B. Genetycznie uwarunkowane zespoły chorobowe związane z przedwczesnym starzeniem. Post Dermatol Alergol 2010; 27. ; 4: 282–290.
- Yu CE, Oshima J, Fu YH, et al. Positional cloning of the Werner's syndrome gene. Science. 1996; 272(5259): 258–262.
- Oshima J. Werner Syndrome. Chromosomal Instability and Aging. 2009.
- Handargal N, Muralidharan J, Sharma PP, et al. Adult Progeria: Werner Syndrome. J Assoc Physicians India. 2016; 64(4): 93–94.
- Lauper JM, Krause A, Vaughan TL, et al. Spectrum and risk of neoplasia in Werner syndrome: a systematic review. PLoS One. 2013; 8(4): e59709.
- Huang S, Lee L, Hanson NB, et al. The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat. 2006; 27(6): 558–567.
- Agrelo R, Sutz MA, Setien F, et al. A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies. Epigenetics. 2015; 10(4): 329–341.
- Lipsker D. What Is Poikiloderma? Dermatology. 2003; 207(3): 243–245.