open access
Vol 82, No 4 (2023)
Review article
Submitted: 2022-10-17
Accepted: 2022-11-09
Published online: 2022-11-30
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Nucleus pulposus cells degeneration model: a necessary way to study intervertebral disc degeneration
1, 1, 1, 1, 1, 1
Affiliations- Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China
open access
Vol 82, No 4 (2023)
REVIEW ARTICLES
Submitted: 2022-10-17
Accepted: 2022-11-09
Published online: 2022-11-30
Abstract
The availability of an appropriate and reliable research model is helpful for researchers
to understand the occurrence and development of diseases. Historically,
animal models have been beneficial in the study of intervertebral disc degenerative
diseases, but intervertebral disc degeneration (IDD) is a precise and complex
process that needs to appear and occur in a specific tissue microenvironment,
and animal degeneration models cannot fully simulate these parameters. These
challenges must be overcome, especially when animal models cannot fully generalise
the complex pathology of humans. In the past few years, the research on
the cell disease model has made important progress, and the construction of the
nucleus pulposus cell (NPC) degeneration model has become an indispensable
step in studying the occurrence and development of IDD. Here, several different
methods of constructing NPC degeneration models and indicators for testing
the effect of modelling are introduced. The practical applications of cell models
constructed by different methods are enumerated to screen and evaluate effective
methods of establishing degenerative cell models and explore the mechanism of
IDD.
Abstract
The availability of an appropriate and reliable research model is helpful for researchers
to understand the occurrence and development of diseases. Historically,
animal models have been beneficial in the study of intervertebral disc degenerative
diseases, but intervertebral disc degeneration (IDD) is a precise and complex
process that needs to appear and occur in a specific tissue microenvironment,
and animal degeneration models cannot fully simulate these parameters. These
challenges must be overcome, especially when animal models cannot fully generalise
the complex pathology of humans. In the past few years, the research on
the cell disease model has made important progress, and the construction of the
nucleus pulposus cell (NPC) degeneration model has become an indispensable
step in studying the occurrence and development of IDD. Here, several different
methods of constructing NPC degeneration models and indicators for testing
the effect of modelling are introduced. The practical applications of cell models
constructed by different methods are enumerated to screen and evaluate effective
methods of establishing degenerative cell models and explore the mechanism of
IDD.
Get Citation
Keywords
human cell model, intervertebral disc degeneration, disease modelling, nucleus pulposus cell, methods
About this articleTitle
Nucleus pulposus cells degeneration model: a necessary way to study intervertebral disc degeneration
Journal
Issue
Article type
Review article
Pages
745-757
Published online
2022-11-30
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1066
Article views/downloads
658
DOI
Pubmed
Bibliographic record
Folia Morphol 2023;82(4):745-757.
Keywords
human cell model
intervertebral disc degeneration
disease modelling
nucleus pulposus cell
methods
Authors
Y.-X. Li
X.-X. Ma
Ch.-L. Zhao
J.-H. Wei
A.-H. Mei
Y. Liu
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