open access

Ahead of Print
Review article
Published online: 2020-12-05
Submitted: 2020-07-28
Accepted: 2020-11-12
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Morphological and functional characteristics of satellite glial cells in the peripheral nervous system

A. Milosavljević, J. Jančić, A. Mirčić, A. Dožić, J. Boljanović, M. Milisavljević, M. Ćetković
DOI: 10.5603/FM.a2020.0141
·
Pubmed: 33330971

open access

Ahead of Print
REVIEW ARTICLES
Published online: 2020-12-05
Submitted: 2020-07-28
Accepted: 2020-11-12

Abstract

Satellite glial cells are specialized cells that form a functional perineuronal sheath around sensory ganglion neurons. There are a large number of studies that reveal the morphological and functional characteristics of these cells. Satellite glial cells have been studied both in intact ganglions and in tissue cultures, using light and transmission electron microscopy, immunohistochemical and other methods. Satellite glial cells have polygonal form; they are mononuclear and have developed synthetic organelles, numerous receptors, adhesion molecules and ion channels, which enable them to interact with adjacent neurons, as well as transmit signals in the ganglions of the peripheral nervous system. Based on the literature data, satellite glial cells thanks to their characteristics can receive signals from other cells and react to changes in their surroundings. Previous studies have investigated the potential role of satellite glial cells in the formation of the blood-nervous tissue barrier of the peripheral nervous system, as well as in the neuropathic pain genesis. Some recent discoveries support the fact that satellite glial cells can participate in controlling of local viral infections and protecting pseudounipolar neurons from mentioned infections.

Abstract

Satellite glial cells are specialized cells that form a functional perineuronal sheath around sensory ganglion neurons. There are a large number of studies that reveal the morphological and functional characteristics of these cells. Satellite glial cells have been studied both in intact ganglions and in tissue cultures, using light and transmission electron microscopy, immunohistochemical and other methods. Satellite glial cells have polygonal form; they are mononuclear and have developed synthetic organelles, numerous receptors, adhesion molecules and ion channels, which enable them to interact with adjacent neurons, as well as transmit signals in the ganglions of the peripheral nervous system. Based on the literature data, satellite glial cells thanks to their characteristics can receive signals from other cells and react to changes in their surroundings. Previous studies have investigated the potential role of satellite glial cells in the formation of the blood-nervous tissue barrier of the peripheral nervous system, as well as in the neuropathic pain genesis. Some recent discoveries support the fact that satellite glial cells can participate in controlling of local viral infections and protecting pseudounipolar neurons from mentioned infections.

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Keywords

satellite glial cell, sensory ganglion, peripheral nervous system, pseudounipolar neuron

About this article
Title

Morphological and functional characteristics of satellite glial cells in the peripheral nervous system

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Review article

Published online

2020-12-05

DOI

10.5603/FM.a2020.0141

Pubmed

33330971

Keywords

satellite glial cell
sensory ganglion
peripheral nervous system
pseudounipolar neuron

Authors

A. Milosavljević
J. Jančić
A. Mirčić
A. Dožić
J. Boljanović
M. Milisavljević
M. Ćetković

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