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Original article
Published online: 2020-07-08
Submitted: 2020-05-20
Accepted: 2020-07-01
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A structural magnetic resonance imaging study in therapy naïve transsexual individuals

A. Starcevic, M. Dakovic, Z. Radojicic, B. Filipovic
DOI: 10.5603/FM.a2020.0073
·
Pubmed: 32644184

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-07-08
Submitted: 2020-05-20
Accepted: 2020-07-01

Abstract

Transsexuality is explaned and defined as a gender-identity disorder, characterized by very strong conviction of belonging to the opposite sex and has been associated with a distinct neuroanatomical pattern. We performed a structural analysis in search of possible differences in gray matter structures based on MRI scans of the brains of 26 individuals between 19 and 38 years of age. The participants were divided into two groups of 15 controls and 11 transgender individuals.The segmentation of subcortical gray matter was performed using the First, the model based segmentation/registration tool, from FSL software package.The results showed that the volume of the brain region called nucleus accumbens on the left side was significantly smaller in the group of transgender individuals compared to the control. It was the most importanat parametar which was shown to make distinction between two examined groups.The results also showed decreased volumes of the left thalamus, right hippocampus and right caudate nucleus.

Abstract

Transsexuality is explaned and defined as a gender-identity disorder, characterized by very strong conviction of belonging to the opposite sex and has been associated with a distinct neuroanatomical pattern. We performed a structural analysis in search of possible differences in gray matter structures based on MRI scans of the brains of 26 individuals between 19 and 38 years of age. The participants were divided into two groups of 15 controls and 11 transgender individuals.The segmentation of subcortical gray matter was performed using the First, the model based segmentation/registration tool, from FSL software package.The results showed that the volume of the brain region called nucleus accumbens on the left side was significantly smaller in the group of transgender individuals compared to the control. It was the most importanat parametar which was shown to make distinction between two examined groups.The results also showed decreased volumes of the left thalamus, right hippocampus and right caudate nucleus.

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Keywords

transsexuals, magnetic resonance imaging, FSL, subcortical brain structures

About this article
Title

A structural magnetic resonance imaging study in therapy naïve transsexual individuals

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Original article

Published online

2020-07-08

DOI

10.5603/FM.a2020.0073

Pubmed

32644184

Keywords

transsexuals
magnetic resonance imaging
FSL
subcortical brain structures

Authors

A. Starcevic
M. Dakovic
Z. Radojicic
B. Filipovic

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