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ORIGINAL ARTICLES
Published online: 2020-05-18
Submitted: 2020-01-14
Accepted: 2020-04-24
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GPER1, estrogen receptors and androgen receptor in the sand rat (Psammomys obesus) efferent ducts

R. Menad, M. Fernini, L. Lakabi, N. Soudani, S. Smaï, X. Bonnet, T. Gernigon-Spychalowicz, E. Moudilou, J.-M. Exbrayat
DOI: 10.5603/FM.a2020.0053
·
Pubmed: 32459366

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-05-18
Submitted: 2020-01-14
Accepted: 2020-04-24

Abstract

The efferent ducts are mainly involved in the reabsorption of the seminiferous tubular fluid. Testosterone as well as estrogens regulate efferent ducts functions via their receptors. This paper presents an experimental investigation on the location of the P450 aromatase, the 17-beta-estradiol (E2), the androgen receptor (AR), the estrogen receptor 1 (ESR1), the estrogen receptor 2 (ESR2) and the G protein-coupled estrogen receptor 1 (GPER1) in the efferent ducts using psammomys obesus as an animal model to highlight the effect of the season on the histology and the distribution of these receptors. We observed a proliferation of the connective tissue, decreasing in the height of the epithelium during the resting season compared to the breeding season. Ciliated cells expressed P450 aromatase, AR, E2, ESR1, ESR2 and GPER1 during both seasons. Basal cells showed a positive staining for the ESR1 and the GPER1 during both season, the AR and E2 during the breeding season and ESR2 during the resting season. Our result shows that the expression of androgen receptor as well as estrogen receptors in the efferent ducts vary by season witch suggest that they are largely involved in the regulation of the efferent ducts functions.

Abstract

The efferent ducts are mainly involved in the reabsorption of the seminiferous tubular fluid. Testosterone as well as estrogens regulate efferent ducts functions via their receptors. This paper presents an experimental investigation on the location of the P450 aromatase, the 17-beta-estradiol (E2), the androgen receptor (AR), the estrogen receptor 1 (ESR1), the estrogen receptor 2 (ESR2) and the G protein-coupled estrogen receptor 1 (GPER1) in the efferent ducts using psammomys obesus as an animal model to highlight the effect of the season on the histology and the distribution of these receptors. We observed a proliferation of the connective tissue, decreasing in the height of the epithelium during the resting season compared to the breeding season. Ciliated cells expressed P450 aromatase, AR, E2, ESR1, ESR2 and GPER1 during both seasons. Basal cells showed a positive staining for the ESR1 and the GPER1 during both season, the AR and E2 during the breeding season and ESR2 during the resting season. Our result shows that the expression of androgen receptor as well as estrogen receptors in the efferent ducts vary by season witch suggest that they are largely involved in the regulation of the efferent ducts functions.

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Keywords

GPER1, ERs, AR, aromatase, efferent ducts, sand rat

About this article
Title

GPER1, estrogen receptors and androgen receptor in the sand rat (Psammomys obesus) efferent ducts

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2020-05-18

DOI

10.5603/FM.a2020.0053

Pubmed

32459366

Keywords

GPER1
ERs
AR
aromatase
efferent ducts
sand rat

Authors

R. Menad
M. Fernini
L. Lakabi
N. Soudani
S. Smaï
X. Bonnet
T. Gernigon-Spychalowicz
E. Moudilou
J.-M. Exbrayat

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