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Original article
Published online: 2020-04-10
Submitted: 2020-02-18
Accepted: 2020-04-07
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Morphological particularities and morphometry of rats’ kidneys under the effect of experimental mild traumatic brain injury

R. Prus, P. Pokotylo, M. Logash, T. Zvir
DOI: 10.5603/FM.a2020.0044
·
Pubmed: 32301101

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-04-10
Submitted: 2020-02-18
Accepted: 2020-04-07

Abstract

Background: Traumatic brain injury is one of the most serious problems of modern medicine that plays the dominant role in the morbidity and mortality of population of the economically developed countries. This article presents the findings of the experimental study of the effect of a mild traumatic brain injury (TBI) on the morphology of rats’ kidney. Material and methods: The experiment was performed on 70 adult white rats 3 months of age. The mild TBI was modeled by the Impact-Acceleration Model - free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, 21st days after TBI.

Results: Examination of the rat’s kidney histological slides on the 1st, 3rd, 5th, 7th, 14th, and 21st days after the traumatic brain injury showed manifested changes in the bloodstream and structural changes in the kidney parenchyma, particularly, dilatation of the capillaries and veins in the initial period. It also showed perivascular lymphocytic infiltration, dystrophic and necrotic processes in the form of the focal destruction of the renal tubule, and renal corpuscles with diapedesis and perivascular hemorrhages on the 5th and 7th days after the TBI. There were also the focal signs of perivascular and glomerular sclerosis observed on the 14th and 21st days after the injury.

Conclusions: The greatest changes in the rats’ kidneys appear on the 5th – 7th days after the injury, which have a clear tendency to decrease after that.

Abstract

Background: Traumatic brain injury is one of the most serious problems of modern medicine that plays the dominant role in the morbidity and mortality of population of the economically developed countries. This article presents the findings of the experimental study of the effect of a mild traumatic brain injury (TBI) on the morphology of rats’ kidney. Material and methods: The experiment was performed on 70 adult white rats 3 months of age. The mild TBI was modeled by the Impact-Acceleration Model - free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, 21st days after TBI.

Results: Examination of the rat’s kidney histological slides on the 1st, 3rd, 5th, 7th, 14th, and 21st days after the traumatic brain injury showed manifested changes in the bloodstream and structural changes in the kidney parenchyma, particularly, dilatation of the capillaries and veins in the initial period. It also showed perivascular lymphocytic infiltration, dystrophic and necrotic processes in the form of the focal destruction of the renal tubule, and renal corpuscles with diapedesis and perivascular hemorrhages on the 5th and 7th days after the TBI. There were also the focal signs of perivascular and glomerular sclerosis observed on the 14th and 21st days after the injury.

Conclusions: The greatest changes in the rats’ kidneys appear on the 5th – 7th days after the injury, which have a clear tendency to decrease after that.

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Keywords

traumatic brain injury, TBI, kidney, rat, nephron

About this article
Title

Morphological particularities and morphometry of rats’ kidneys under the effect of experimental mild traumatic brain injury

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Original article

Published online

2020-04-10

DOI

10.5603/FM.a2020.0044

Pubmed

32301101

Keywords

traumatic brain injury
TBI
kidney
rat
nephron

Authors

R. Prus
P. Pokotylo
M. Logash
T. Zvir

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