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Morphological particularities and morphometry of rats’ kidneys under the effect of experimental mild traumatic brain injury
, 2, 3
Affiliations- Department of Pathological Anatomy with Section Course, Odessa National Medical University, Odessa, Ukraine
- Department of Normal Anatomy, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
- Liaison Librarian, The Catholic University of America, Washington, United States
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Abstract
Background: Traumatic brain injury (TBI) is one of the most serious problems of modern medicine that plays the dominant role in the morbidity and mortality of population of the economically developed countries. This article presents the findings of the experimental study of the effect of a mild TBI on the morphology of rats’ kidney. Materials and methods: The experiment was performed on 70 adult white rats 3 months of age. The mild TBI was modelled by the Impact-Acceleration Model — free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, 21st days after TBI. Results: Examination of the rat’s kidney histological slides on the 1st, 3rd, 5th, 7th, 14th, and 21st days after the TBI showed manifested changes in the bloodstream and structural changes in the kidney parenchyma, particularly, dilatation of the capillaries and veins in the initial period. It also showed perivascular lymphocytic infiltration, dystrophic and necrotic processes in the form of the focal destruction of the renal tubule, and renal corpuscles with diapedesis and perivascular haemorrhages on the 5th and 7th days after the TBI. There were also the focal signs of perivascular and glomerular sclerosis observed on the 14th and 21st days after the injury. Conclusions: The greatest changes in the rats’ kidneys appear on the 5th–7th days after the injury, which have a clear tendency to decrease after that.
Abstract
Background: Traumatic brain injury (TBI) is one of the most serious problems of modern medicine that plays the dominant role in the morbidity and mortality of population of the economically developed countries. This article presents the findings of the experimental study of the effect of a mild TBI on the morphology of rats’ kidney. Materials and methods: The experiment was performed on 70 adult white rats 3 months of age. The mild TBI was modelled by the Impact-Acceleration Model — free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, 21st days after TBI. Results: Examination of the rat’s kidney histological slides on the 1st, 3rd, 5th, 7th, 14th, and 21st days after the TBI showed manifested changes in the bloodstream and structural changes in the kidney parenchyma, particularly, dilatation of the capillaries and veins in the initial period. It also showed perivascular lymphocytic infiltration, dystrophic and necrotic processes in the form of the focal destruction of the renal tubule, and renal corpuscles with diapedesis and perivascular haemorrhages on the 5th and 7th days after the TBI. There were also the focal signs of perivascular and glomerular sclerosis observed on the 14th and 21st days after the injury. Conclusions: The greatest changes in the rats’ kidneys appear on the 5th–7th days after the injury, which have a clear tendency to decrease after that.
Keywords
traumatic brain injury, kidney, rat, nephron
About this articleTitle
Morphological particularities and morphometry of rats’ kidneys under the effect of experimental mild traumatic brain injury
Journal
Issue
Article type
Original article
Pages
310-316
Published online
2020-04-10
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1211
Article views/downloads
1254
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(2):310-316.
Keywords
traumatic brain injury
kidney
rat
nephron
Authors
R. Prus
P. Pokotylo
M. Logash
T. Zvir
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