Vol 79, No 1 (2020)
Original article
Published online: 2019-04-16

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Position and size of massa intermedia in Serbian brains

M. N. Pavlović1, I. D. Jovanović1, S. Z. Ugrenović1, A. V. Kostić2, B. K. Kundalić1, V. R. Stojanović1, S. Vlajković1, M. M. Trandafilović1, J. R. Čukuranović-Kokoris1, M. M. Antić1
Pubmed: 30993663
Folia Morphol 2020;79(1):21-27.

Abstract

Background: Massa intermedia, a midline bar-shaped structure, connects two thalami across the third ventricle in 70–80% of healthy humans. It has become clinically important since its absence was comprehended as a midline malformation of the brain and brought in connection with schizophrenia indicating that some symptoms could be a consequence of disturbed neuron chains underlying the mechanisms of attention and processing of information. The aim of the investigation was to find out the incidence, position, and size of massa intermedia in the brains of the Serbian population. Materials and methods: Our investigation was performed on 41 brains of adult Serbian cadavers using a macro dissection method. Results: Massa intermedia was present in 80.49% of cases, in 1 case it was double. In most of the cases it was located in the superior quadrants of the lateral wall of the third ventricle, the larger part being in the anterosuperior one. Some other combinations were also present. The horizontal diameter of the cross-section was larger than vertical and was not in correlation with the length of the third ventricle. The average cross-sectional area was 29.58 mm2, significantly larger in females. Conclusions: Massa intermedia is present in most of the investigated brains, usually connecting the anterior-superior quadrants of the lateral walls of the third ventricle. Different in shape and size its cross-section is a horizontal ellipse, significantly larger in females. The cross-sectional area and the size of the third ventricle are not in correlation.

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References

  1. Agarwal N, Rambaldelli G, Perlini C, et al. Microstructural thalamic changes in schizophrenia: a combined anatomic and diffusion weighted magnetic resonance imaging study. J Psychiatry Neurosci. 2008; 33(5): 440–448.
  2. Allen LS, Gorski RA. Sexual dimorphism of the anterior commissure and massa intermedia of the human brain. J Comp Neurol. 1991; 312(1): 97–104.
  3. Baydin S, Gungor A, Baran O, et al. The double massa intermedia. Surg Neurol Int. 2016; 7: 30.
  4. Carpenter MB. Thalamus in: core text of neuroanatomy. 4th ed. Williams&Wilkins, Baltimore 1996: 49–50.
  5. Cataltepe O. Endoscopic third ventriculostomy: indications, surgical technique, and potential problems. Turk Neurosurg. 2002; 12: 65–73.
  6. Ceyhan M, Adapınar B, Aksaray G, et al. Absence and size of massa intermedia in patients with schizophrenia and bipolar disorder. Acta Neuropsychiatr. 2008; 20(4): 193–198.
  7. Di Rocco C. Massa intermedia: mental development. Childs Nerv Syst. 2005; 21(12): 1013–1017.
  8. Collins P. Embriology and development. In: Williams PL (ed.) Gray’s anatomy. 38th ed. Churchill Livingstone, London 1995: 91–328.
  9. de Souza Crippa JA, Zuardi AW, Busatto GF, et al. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. Eur Psychiatry. 2006; 21(5): 291–299.
  10. Erbağci H, Yildirim H, Herken H, et al. A magnetic resonance imaging study of the adhesio interthalamica in schizophrenia. Schizophr Res. 2002; 55(1-2): 89–92.
  11. Haghir H, Mokhber N, Azarpazhooh MR, et al. A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia. Indian J Psychiatry. 2013; 55(2): 135–139.
  12. Hirayasu Y, Wada JA. N-methyl-D-aspartate injection into the massa intermedia facilitates development of limbic kindling in rats. Epilepsia. 1992; 33(6): 965–970.
  13. Ligier Y, Ratib O, Logean M, et al. Osiris: a medical image-manipulation system. MD Comput. 1994; 11(4): 212–218.
  14. Malobabić S, Puskas L, Blagotić M. Size and position of the human adhaesio interthalamica. Gegenbaurs Morphol Jahrb. 1987; 133(1): 175–180.
  15. Meisenzahl EM, Frodl T, Zetzsche T, et al. Adhesio interthalamica in male patients with schizophrenia. Am J Psychiatry. 2000; 157(5): 823–825.
  16. Mori H, Oi S, Nonaka Y, et al. Ventricular anatomy of hydrocephalus associated with myeloschisis and endoscopic third ventriculostomy. Childs Nerv Syst. 2008; 24(6): 717–722.
  17. Nayak SB, Soumya KV. Unusually large interthalamic adhesion and its clinical importance. Int J Anat Var. 2010; 3: 174–175.
  18. Nopoulos P, Swayze V, Flaum M, et al. Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging. Biol Psychiatry. 1997; 41(11): 1102–1108.
  19. Nopoulos PC, Rideout D, Crespo-Facorro B, et al. Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls. Schizophr Res. 2001; 48(2-3): 177–185.
  20. Park K, Lee H, Chung I, et al. A morphologic study of interthalamic adhesions in Korean brains. Clini Anat. 1993; 6(1): 33–36.
  21. Puskas L, Malobabić S, Puskas N, et al. Specific circular organization of the neurons of human interthalamic adhesion and of periventricular thalamic region. Int J Neurosci. 2005; 115(5): 669–679.
  22. Rosales RK, Lemay MJ, Yakovley PI. The development and involution of massa intermedia with regard to age and sex. J Neuropathol Exp Neurol. 1968; 27(1): 166.
  23. Sen F, Ulabay H, Ozeksi P, et al. Morphometric measurements of the thalamus and interhemispheric adhesion by MR imaging. Neuroanat. 2005; 4: 10–12.
  24. Shimizu M, Fujiwara H, Hirao K, et al. Structural abnormalities of the adhesio interthalamica and mediodorsal nuclei of the thalamus in schizophrenia. Schizophr Res. 2008; 101(1-3): 331–338.
  25. Snyder PJ, Bogerts B, Wu H, et al. Absence of the adhesio interthalamica as a marker of early developmental neuropathology in schizophrenia: an MRI and postmortem histologic study. J Neuroimaging. 1998; 8(3): 159–163.
  26. Susser E, Brown AS, Klonowski E, et al. Schizophrenia and impaired homocysteine metabolism: a possible association. Biol Psychiatry. 1998; 44(2): 141–143.
  27. Takahashi T, Suzuki M, Zhou SY, et al. Prevalence and length of the adhesio interthalamica in schizophrenia spectrum disorders. Psychiatry Res. 2008; 164(1): 90–94.
  28. Takahashi T, Suzuki M, Nakamura K, et al. Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia. Psychiatry Res. 2008; 162(2): 101–111.
  29. Trzesniak C, Kempton MJ, Busatto GF, et al. Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(4): 877–886.
  30. Trzesniak C, Linares IM, Coimbra ÉR, et al. Adhesio interthalamica and cavum septum pellucidum in mesial temporal lobe epilepsy. Brain Imaging Behav. 2016; 10(3): 849–856.
  31. Tubbs RS, Smyth MD, Oakes WJ, et al. Duplication of the massa intermedia in a child. Pediatr Neurosurg. 2004; 40(1): 42–43.
  32. Wright P, Takei N, Rifkin L, et al. Maternal influenza, obstetric complications, and schizophrenia. Am J Psychiatry. 1995; 152(12): 1714–1720.