open access

Vol 82, No 4 (2023)
Review article
Submitted: 2022-10-17
Accepted: 2022-11-09
Published online: 2022-11-30
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Nucleus pulposus cells degeneration model: a necessary way to study intervertebral disc degeneration

Y.-X. Li1, X.-X. Ma1, Ch.-L. Zhao1, J.-H. Wei1, A.-H. Mei1, Y. Liu1
·
Pubmed: 36472394
·
Folia Morphol 2023;82(4):745-757.
Affiliations
  1. Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China

open access

Vol 82, No 4 (2023)
REVIEW ARTICLES
Submitted: 2022-10-17
Accepted: 2022-11-09
Published online: 2022-11-30

Abstract

The availability of an appropriate and reliable research model is helpful for researchers
to understand the occurrence and development of diseases. Historically,
animal models have been beneficial in the study of intervertebral disc degenerative
diseases, but intervertebral disc degeneration (IDD) is a precise and complex
process that needs to appear and occur in a specific tissue microenvironment,
and animal degeneration models cannot fully simulate these parameters. These
challenges must be overcome, especially when animal models cannot fully generalise
the complex pathology of humans. In the past few years, the research on
the cell disease model has made important progress, and the construction of the
nucleus pulposus cell (NPC) degeneration model has become an indispensable
step in studying the occurrence and development of IDD. Here, several different
methods of constructing NPC degeneration models and indicators for testing
the effect of modelling are introduced. The practical applications of cell models
constructed by different methods are enumerated to screen and evaluate effective
methods of establishing degenerative cell models and explore the mechanism of
IDD.

Abstract

The availability of an appropriate and reliable research model is helpful for researchers
to understand the occurrence and development of diseases. Historically,
animal models have been beneficial in the study of intervertebral disc degenerative
diseases, but intervertebral disc degeneration (IDD) is a precise and complex
process that needs to appear and occur in a specific tissue microenvironment,
and animal degeneration models cannot fully simulate these parameters. These
challenges must be overcome, especially when animal models cannot fully generalise
the complex pathology of humans. In the past few years, the research on
the cell disease model has made important progress, and the construction of the
nucleus pulposus cell (NPC) degeneration model has become an indispensable
step in studying the occurrence and development of IDD. Here, several different
methods of constructing NPC degeneration models and indicators for testing
the effect of modelling are introduced. The practical applications of cell models
constructed by different methods are enumerated to screen and evaluate effective
methods of establishing degenerative cell models and explore the mechanism of
IDD.

Get Citation

Keywords

human cell model, intervertebral disc degeneration, disease modelling, nucleus pulposus cell, methods

About this article
Title

Nucleus pulposus cells degeneration model: a necessary way to study intervertebral disc degeneration

Journal

Folia Morphologica

Issue

Vol 82, No 4 (2023)

Article type

Review article

Pages

745-757

Published online

2022-11-30

Page views

1068

Article views/downloads

659

DOI

10.5603/FM.a2022.0102

Pubmed

36472394

Bibliographic record

Folia Morphol 2023;82(4):745-757.

Keywords

human cell model
intervertebral disc degeneration
disease modelling
nucleus pulposus cell
methods

Authors

Y.-X. Li
X.-X. Ma
Ch.-L. Zhao
J.-H. Wei
A.-H. Mei
Y. Liu

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By VM Media Group sp. z o.o., Grupa Via Medica, Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.: +48 58 320 94 94, faks: +48 58 320 94 60, e-mail: viamedica@viamedica.pl