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ORIGINAL ARTICLES
Published online: 2019-01-03
Submitted: 2018-10-16
Accepted: 2018-12-05
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Three-dimensional modelling of the femur and humerus in adult male guinea pigs (guinea pig) with computed tomography and some biometric measurement values

Mustafa Orhun Dayan, Kamil Beşoluk, Emrullah Eken, Sedat Aydoğdu, Nimet Turgut
DOI: 10.5603/FM.a2019.0002
·
Pubmed: 30644082

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2019-01-03
Submitted: 2018-10-16
Accepted: 2018-12-05

Abstract

Background: Guinea pig is a species belonging to the Caviidae family of the Rodentia order and is frequently used in experimental studies. Biomedical imaging methods are used in the diagnosis and treatment of many diseases in medicine. Among these methods, computed tomography (CT) is one of the most important imaging methods. In this study, it was aimed to perform the three-dimensional modelling of the CT images, obtained from the humerus and femur in the guinea pigs, via the MIMICS programme and to make some biometric measurements regarding the bones over these models.

Materials and methods: In the present study, 12 male adult guinea pigs were used. The soft tissue on humerus and femur bones of the guinea pigs was removed. After this procedure, CT images at a 0.5 mm-thickness were obtained from the animals.  The images were recorded in DICOM format. Then, the reconstruction process was performed from the images by using the three-dimensional modelling programme MIMICS® 13.1. On the 3D model of the humerus and femur (right-left), volumes, surface areas and lengths as well as other biometric parameters were measured separately, and the values were recorded. In addition, measurements of the bones were made by the help of a digital calliper.

Results: Among the parameters obtained from 3D models, a statistical difference is observed between the right and left cortex thicknesses of the femur from the measurements of calliper and the right and left humerus volumes (p<0.05); whereas, no statistical difference was found in other parameters of both measurements (p>0.05).

Conclusions: It can be stated that CT and 3D modelling can be used for the measurement of some parameters in the long bones of the guinea pigs.

Abstract

Background: Guinea pig is a species belonging to the Caviidae family of the Rodentia order and is frequently used in experimental studies. Biomedical imaging methods are used in the diagnosis and treatment of many diseases in medicine. Among these methods, computed tomography (CT) is one of the most important imaging methods. In this study, it was aimed to perform the three-dimensional modelling of the CT images, obtained from the humerus and femur in the guinea pigs, via the MIMICS programme and to make some biometric measurements regarding the bones over these models.

Materials and methods: In the present study, 12 male adult guinea pigs were used. The soft tissue on humerus and femur bones of the guinea pigs was removed. After this procedure, CT images at a 0.5 mm-thickness were obtained from the animals.  The images were recorded in DICOM format. Then, the reconstruction process was performed from the images by using the three-dimensional modelling programme MIMICS® 13.1. On the 3D model of the humerus and femur (right-left), volumes, surface areas and lengths as well as other biometric parameters were measured separately, and the values were recorded. In addition, measurements of the bones were made by the help of a digital calliper.

Results: Among the parameters obtained from 3D models, a statistical difference is observed between the right and left cortex thicknesses of the femur from the measurements of calliper and the right and left humerus volumes (p<0.05); whereas, no statistical difference was found in other parameters of both measurements (p>0.05).

Conclusions: It can be stated that CT and 3D modelling can be used for the measurement of some parameters in the long bones of the guinea pigs.

Get Citation

Keywords

computed tomography, femur, humerus, guinea pig, three-dimensional reconstruction

About this article
Title

Three-dimensional modelling of the femur and humerus in adult male guinea pigs (guinea pig) with computed tomography and some biometric measurement values

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2019-01-03

DOI

10.5603/FM.a2019.0002

Pubmed

30644082

Keywords

computed tomography
femur
humerus
guinea pig
three-dimensional reconstruction

Authors

Mustafa Orhun Dayan
Kamil Beşoluk
Emrullah Eken
Sedat Aydoğdu
Nimet Turgut

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