Interstitial cells of Cajal — systematic review

Abstract

This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastro­intestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in as well as in GI stromal tumours are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.