Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats

Abstract

The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1 - 3.5 mg/kg, P2 - 35.0 mg/kg, P3 - 350.0 mg/kg. The foetuses were delivered by laparotomy on the 21^st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.