open access

Vol 59, No 3 (2000)
ORIGINAL ARTICLES
Published online: 2000-07-06
Submitted: 2012-02-06
Get Citation

Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats

Franciszek Burdan
Folia Morphol 2000;59(3):167-172.

open access

Vol 59, No 3 (2000)
ORIGINAL ARTICLES
Published online: 2000-07-06
Submitted: 2012-02-06

Abstract

The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1 - 3.5 mg/kg, P2 - 35.0 mg/kg, P3 - 350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.

Abstract

The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1 - 3.5 mg/kg, P2 - 35.0 mg/kg, P3 - 350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.
Get Citation

Keywords

paracetamol; acetaminophen; congenital-malformation;

About this article
Title

Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats

Journal

Folia Morphologica

Issue

Vol 59, No 3 (2000)

Pages

167-172

Published online

2000-07-06

Bibliographic record

Folia Morphol 2000;59(3):167-172.

Keywords

paracetamol
acetaminophen
congenital-malformation

Authors

Franciszek Burdan

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By  "Via Medica sp. z o.o." sp.k., Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl