Vol 59, No 3 (2000)
Review article
Submitted: 2012-02-06
Published online: 2000-07-06
Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
Jarosław Zaremba
Folia Morphol 2000;59(3):137-144.
Vol 59, No 3 (2000)
REVIEW ARTICLES
Submitted: 2012-02-06
Published online: 2000-07-06
Abstract
Tumor necrosis factor alpha (TNF-alpha) is a protein of a cellular origin belonging to a group of proinflammatory cytokines. A rapid overproduction of TNF-alpha in a cerebral post-ischemic inflammatory response leads to the stimulation of adhesive molecules expression with subsequent accumulation of leukocytes in the ischemic focus, which is preceded by their adhesion and migration. The TNF-alpha proinflammatory activity results mainly in extending the area of the brain infarct, which brings about negative clinical implications. Being the final morphological effect of ischemic stroke, TNF-alpha appears also to contribute to neuronal necrosis by its involvement in the process of apoptosis as well as in the death of neurons. The present study describes and discusses mainly the contribution of TNF-alpha to the formation of ischemic focus in the brain.
Abstract
Tumor necrosis factor alpha (TNF-alpha) is a protein of a cellular origin belonging to a group of proinflammatory cytokines. A rapid overproduction of TNF-alpha in a cerebral post-ischemic inflammatory response leads to the stimulation of adhesive molecules expression with subsequent accumulation of leukocytes in the ischemic focus, which is preceded by their adhesion and migration. The TNF-alpha proinflammatory activity results mainly in extending the area of the brain infarct, which brings about negative clinical implications. Being the final morphological effect of ischemic stroke, TNF-alpha appears also to contribute to neuronal necrosis by its involvement in the process of apoptosis as well as in the death of neurons. The present study describes and discusses mainly the contribution of TNF-alpha to the formation of ischemic focus in the brain.
Keywords
tumor necrosis factor alpha (TNF-alpha); proinflammatory cytokines; stroke
Title
Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
Journal
Folia Morphologica
Issue
Vol 59, No 3 (2000)
Article type
Review article
Pages
137-144
Published online
2000-07-06
Page views
584
Article views/downloads
1342
Bibliographic record
Folia Morphol 2000;59(3):137-144.
Keywords
tumor necrosis factor alpha (TNF-alpha)
proinflammatory cytokines
stroke