open access

Vol 60, No 1 (2001)
ORIGINAL ARTICLES
Published online: 2000-11-09
Submitted: 2012-02-06
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Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection

Krzystof Lutnicki, Ewa Szpringer, Krystian Czerny, Andrzej Ledwożyw
Folia Morphol 2001;60(1):47-56.

open access

Vol 60, No 1 (2001)
ORIGINAL ARTICLES
Published online: 2000-11-09
Submitted: 2012-02-06

Abstract

Cytoprotection in the stomach, consisting in the mucus secretion, mucous circulation intensification and bicarbonate secretion to the gastric lumen, is highly dependent on the products of arachidonic acid pathway and peroxidative-antioxidative balance. The aim of the paper was to examine the effects of selected inhibitors of arachidonic acid pathway on the natural protective system of the gastric mucosa exposed to 50% ethanol. The results show that leukotrienes, thromboxane and oxygen reactive forms significantly impair the protective function of the gastric mucosa while prostaglandins and antioxidant enzymes act protectively.

Abstract

Cytoprotection in the stomach, consisting in the mucus secretion, mucous circulation intensification and bicarbonate secretion to the gastric lumen, is highly dependent on the products of arachidonic acid pathway and peroxidative-antioxidative balance. The aim of the paper was to examine the effects of selected inhibitors of arachidonic acid pathway on the natural protective system of the gastric mucosa exposed to 50% ethanol. The results show that leukotrienes, thromboxane and oxygen reactive forms significantly impair the protective function of the gastric mucosa while prostaglandins and antioxidant enzymes act protectively.
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Keywords

cytoprotection; ethanol; arachidonic acid pathway inhibitors; oxygen free radicals; antioxidants

About this article
Title

Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection

Journal

Folia Morphologica

Issue

Vol 60, No 1 (2001)

Pages

47-56

Published online

2000-11-09

Bibliographic record

Folia Morphol 2001;60(1):47-56.

Keywords

cytoprotection
ethanol
arachidonic acid pathway inhibitors
oxygen free radicals
antioxidants

Authors

Krzystof Lutnicki
Ewa Szpringer
Krystian Czerny
Andrzej Ledwożyw

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