open access

Vol 60, No 1 (2001)
REVIEW ARTICLES
Published online: 2000-11-09
Submitted: 2012-02-06
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Interstitial cells of Cajal: is their role in gastrointestinal function in view of therapeutic perspectives underestimated or exaggerated?

Jeane-Pierre Timmermans
Folia Morphol 2001;60(1):1-10.

open access

Vol 60, No 1 (2001)
REVIEW ARTICLES
Published online: 2000-11-09
Submitted: 2012-02-06

Abstract

This manuscript reviews the current views on morphology and function of the distinct subpopulations of interstitial cells of Cajal (ICC) in the digestive tract and their interrelationships with surrounding cells. Three different functions have been postulated so far, i.e. a pacemaker role, a mediator in enteric excitatory and inhibitory neurotransmission and a mechanosensor. Attention will also be paid to the interstitial cells of Cajal and their possible involvement in pathophysiological conditions. Finally, perspectives for interstitial cells of Cajal as targets for therapeutic intervention will be discussed.

Abstract

This manuscript reviews the current views on morphology and function of the distinct subpopulations of interstitial cells of Cajal (ICC) in the digestive tract and their interrelationships with surrounding cells. Three different functions have been postulated so far, i.e. a pacemaker role, a mediator in enteric excitatory and inhibitory neurotransmission and a mechanosensor. Attention will also be paid to the interstitial cells of Cajal and their possible involvement in pathophysiological conditions. Finally, perspectives for interstitial cells of Cajal as targets for therapeutic intervention will be discussed.
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Keywords

interstitial cells of Cajal; pacemaker; neurotransmission; slow wave mechanoreceptor; gut

About this article
Title

Interstitial cells of Cajal: is their role in gastrointestinal function in view of therapeutic perspectives underestimated or exaggerated?

Journal

Folia Morphologica

Issue

Vol 60, No 1 (2001)

Pages

1-10

Published online

2000-11-09

Bibliographic record

Folia Morphol 2001;60(1):1-10.

Keywords

interstitial cells of Cajal
pacemaker
neurotransmission
slow wave mechanoreceptor
gut

Authors

Jeane-Pierre Timmermans

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