open access

Vol 61, No 1 (2002)
ORIGINAL ARTICLES
Published online: 2001-11-19
Submitted: 2012-02-06
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Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain

Beata Ludkiewicz, Sławomir Wójcik, Edyta Spodnik, Beata Domaradzka-Pytel, Janusz Moryś
Folia Morphol 2002;61(1):7-14.

open access

Vol 61, No 1 (2002)
ORIGINAL ARTICLES
Published online: 2001-11-19
Submitted: 2012-02-06

Abstract

Immunohistochemical study of the cholinergic innervation of the hippocampal calretinin-containing cells was conducted on 28 rat brains of postnatal ages: P0, P4, P7, P14, P21, P30 and P60. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and calretinin were analysed using confocal laser-scanning microscope. Obtained data demonstrate that during development as well as in adult species calretinin-containing neurones in the rat hippocampus form sparse synaptic contact with VAChT-ir terminals. It seems probable that cholinergic innervation is not crucial for the functioning of CR-ir cells - probably they remain under the greater influence of a system other than the cholinergic system.

Abstract

Immunohistochemical study of the cholinergic innervation of the hippocampal calretinin-containing cells was conducted on 28 rat brains of postnatal ages: P0, P4, P7, P14, P21, P30 and P60. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and calretinin were analysed using confocal laser-scanning microscope. Obtained data demonstrate that during development as well as in adult species calretinin-containing neurones in the rat hippocampus form sparse synaptic contact with VAChT-ir terminals. It seems probable that cholinergic innervation is not crucial for the functioning of CR-ir cells - probably they remain under the greater influence of a system other than the cholinergic system.
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Keywords

hippocampus; development; calretinin; cholinergic system

About this article
Title

Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain

Journal

Folia Morphologica

Issue

Vol 61, No 1 (2002)

Pages

7-14

Published online

2001-11-19

Bibliographic record

Folia Morphol 2002;61(1):7-14.

Keywords

hippocampus
development
calretinin
cholinergic system

Authors

Beata Ludkiewicz
Sławomir Wójcik
Edyta Spodnik
Beata Domaradzka-Pytel
Janusz Moryś

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